This article examines current approaches to understanding the economic security of the regions of the Russian Federation. The analysis of the works of domestic and foreign authors related to the research problem allowed identifying the special role of competent management of economic security in the effective development of territories. Despite the exceptional role of economic security, there are no clear strategies for managing sustainable development at the meso-level. The proposed system for assessing economic security at the level of the country's subjects is based on a systematic approach, which is the methodological basis of the entire study. Statistical parameters determined based on Rosstat data on the directions characterizing the level of economic security at the national level were selected as indicators of the analysis of economic security at the meso-level. In the study, clusters were formed according to the values of mesoparameters in 2022. The use of cluster analysis made it possible to identify regions with similarities according to the proposed criteria for assessing economic security at the level of the subjects of the Russian Federation. The number of groups to split was determined by the Sturgess formula, and the calculated results were also confirmed by graphical analysis of the vertical dendrogram. The graph of the average characteristics of the identi-fied clusters made it possible to analyze similar features of certain regional groups. The study also proposed directions for improving economic security, considering the identified features. These rec-ommendations were determined based on the strengths and weaknesses of the regions that make up each of the clusters.