Economic analysis of the supercritical fluid extraction of lupane-triterpenoids from Acacia dealbata Link bark

Rodrigues, Vítor H.; Portugal, Inês; Silva, Carlos M.

doi:10.1016/j.indcrop.2023.116838

Cited by 4 publications

(9 citation statements)

References 36 publications

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“…The lowest flavonoid content was obtained with water (234 ± 4.3 μg QE/g) (Table ). Supercritical carbon dioxide is a nonpolar solvent where low-polarity compounds are easily dissolved (isoflavones, flavanones), but the addition of a cosolvent, such as ethanol, can enhance the extraction of polar compounds …”

Section: Resultsmentioning

confidence: 99%

“…Supercritical carbon dioxide is a nonpolar solvent where low-polarity compounds are easily dissolved (isoflavones, flavanones), but the addition of a cosolvent, such as ethanol, can enhance the extraction of polar compounds. 14 The EtOH-H 2 O extract showed the highest antioxidant activity with 64.3% inhibition of DPPH, followed by the EtOH extract, oleoresin, and water extract (48.3, 24.3, and 21.3%, respectively) (Table 1). The antioxidant activity was in relation to the amounts of total phenolic compounds and flavonoid content.…”

Section: Phytochemical Screening and Antioxidantmentioning

confidence: 98%

“…These processes have some disadvantages, such as the use of a large number of solvents, low extraction yields, and high extraction temperatures. Supercritical fluid extraction (SFE) using carbon dioxide (CO 2 ) as a solvent is considered a new green technology classified as generally recognized as safe (GRAS), which has motivated its application for the extraction of plant bioactive compounds. , …”

Section: Introductionmentioning

confidence: 99%

“…Supercritical fluid extraction (SFE) using carbon dioxide (CO 2 ) as a solvent is considered a new green technology classified as generally recognized as safe (GRAS), which has motivated its application for the extraction of plant bioactive compounds. 14,15 For all of the above, this study aimed to characterize Chipilin leaf extracts obtained by the traditional maceration process using water, ethanol, and ethanol−water as solvents, as well as the oleoresin obtained by the SFE process. The total phenolic compound and flavonoid contents as well as the antioxidant activity of Chipilin extracts were evaluated by colorimetric methods.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicological and Sedative Effects of Chipilin (Crotalaria longirostrata) Leaf Extracts Obtained by Maceration and Supercritical Fluid Extraction

Hernández-Reyes,

Guzmán-Albores,

De León-Rodríguez

et al. 2024

ACS Omega

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Chipilin (Crotalaria longirostrata) is consumed as a vegetable in the preparation of traditional dishes. As a folk medicine, Chipilin extracts are used as a hypnotic and sedative agent; however, there are few reports that support these uses. This study aimed to characterize the compounds present in Chipilin leaf extracts and to investigate their sedative effect using zebrafish as an in vivo model. Extracts were obtained by maceration with water (H 2 O), ethanol (EtOH), and EtOH-H 2 O, while oleoresin was obtained by supercritical fluid extraction (SFE). Total phenolic and flavonoid contents were quantified by colorimetric methods. Phytochemical constituents were identified by gas chromatography−mass spectrometry (GC-MS) analysis. The chronic and acute toxicities of Chipilin extracts were tested in zebrafish embryos and larvae, respectively. Chipilin sedative effect was tested by the larvae response to dark−light−dark transitions. EtOH-H 2 O extracts had the highest value of total phenolics (5345 ± 5.1 μg GAE/g), followed by water and oleoresin (1815 ± 5.1 and 394 ± 5.1 μg GAE/g, respectively). In water extracts were identified the alkaloid trachelanthamidine, 1,2β-epoxy-and the alkyl ketone 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, while oleamide, αmonostearin, and erucamide were detected in all samples except in water extracts. Oleoresin extract had the lowest embryotoxicity (LC 50 = 4.99 μg/mL) and the highest sedative effects. SFE is a green alternative to obtain Chipilin extracts rich in erucamide, an endocannabinoid analogue, which plays an important role in the development of the central nervous system and in modulating neurotransmitter release.

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Section: Resultsmentioning

confidence: 99%

Section: Phytochemical Screening and Antioxidantmentioning

confidence: 98%