High-quality development efficiency can comprehensively measure the development quality of a region. This study constructed the SE-SBM Model and measured the quality development efficiency of the Yellow River Basin from 2010 to 2019. In panel regression, the periodic effects of industrial structure, environmental regulation, and their interaction terms on the efficiency of high-quality development are analyzed. From the perspective of the threshold effect, we explore the possible threshold of interaction to change the efficiency of high-quality development. The results show: (1) From 2010 to 2019, the high-quality development efficiency of the Yellow River Basin’s watershed segment showed a gradient development trend. (2) In panel regression, the interaction terms positively impact the whole basin’s high-quality development efficiency. However, for different sub-basins, the impact of the core explanatory variable on the efficiency of high-quality development is different. (3) The Yellow River basin has a single significant threshold in the threshold regression. From the perspective of the sub-basin, the upper and lower reaches of the Yellow River have a single significant threshold. There is no threshold in midstream. Based on the research results, the article puts forward relevant suggestions, such as reasonably improving regional imports and exports and introducing high-quality foreign capital, which can provide a basis for relevant departments.