Economic Modeling and Decision Making in the Development and Clinical Application of Tissue Engineering

Vavken, Patrick; Dorotka, Ronald; Gruber, M.

doi:10.1007/978-3-540-77755-7_2

Cited by 2 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, this is the most important limitation of our model, and the reason why a modelling approach was undertaken to estimate the economic impact of cartilage lesion treatment. [68] The model, which currently relies on conservative assumptions, may be adapted as soon as new data become available.…”

Section: Discussionmentioning

confidence: 99%

The Cost Utility of Autologous Chondrocytes Implantation Using ChondroCelect® in Symptomatic Knee Cartilage Lesions in Belgium

Gerlier¹,

Lamotte²,

Wille³

et al. 2010

PharmacoEconomics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The Cost Utility of Autologous Chondrocytes Implantation Using ChondroCelect® in Symptomatic Knee Cartilage Lesions in Belgium

Gerlier¹,

Lamotte²,

Wille³

et al. 2010

PharmacoEconomics

View full text Add to dashboard Cite

show abstract

Designing Biodegradable Shape Memory Polymers for Tissue Repair

Ramaraju

Akman

Safranski

et al. 2020

Adv Funct Materials

View full text Add to dashboard Cite

Shape memory materials, specifically nickel-titanium alloys, are used in a number of minimally invasive clinical procedures demonstrating significant improvements in clinical outcomes and standard of care compared to open procedures. However, concerns regarding erosion events, device failure, and consequent morbidities are driving interest in tissue engineering approaches which support or stimulate the patient's own tissue regenerative processes to repair and regenerate tissues. Growing interest in addressing these challenges using minimally invasive procedures is driving the rapid advancement of a new class of materials; biodegradable shape memory polymers (SMPs). These biodegradable SMPs are designed for compaction and delivery through keyhole incisions, expansion when they reach the target tissue, maintenance of mechanical continuity with surrounding tissues upon implantation, attachment of regenerative cells driving tissue growth and infiltration, and degradation into nontoxic byproducts. Polyesters are predominantly used in the design of these SMPs to impart biodegradability through hydrolysis. Use of homopolymers, copolymers, terpolymers, block-copolymers, and interpenetrating networks has given rise to a range of SMPs spanning applications from endovascular to bone defect repair. Translating these materials to the clinic and applying these materials toward patient specific design can advance the current standard of care across various clinical disciplines.

show abstract

Economic Modeling and Decision Making in the Development and Clinical Application of Tissue Engineering

Cited by 2 publications

References 21 publications

The Cost Utility of Autologous Chondrocytes Implantation Using ChondroCelect® in Symptomatic Knee Cartilage Lesions in Belgium

The Cost Utility of Autologous Chondrocytes Implantation Using ChondroCelect® in Symptomatic Knee Cartilage Lesions in Belgium

Designing Biodegradable Shape Memory Polymers for Tissue Repair

Contact Info

Product

Resources

About