Ecotoxicity induced by total, water soluble and insoluble components of atmospheric fine particulate matter exposure in Caenorhabditis elegans

Liu, Xiaoming; Ge, Pengxiang; Lu, Zhenyu; Cao, Maoyu; Chen, Wankang; Yan, Zhansheng; Chen, Mindong; Wang, Junfeng

doi:10.1016/j.chemosphere.2022.137672

Cited by 5 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, OC and water–soluble ions had a strong correlation with the generation of ROS. The fact that water–soluble ions could break down into cells and stimulate ROS generation might be a significant contributing factor [ 50 , 51 ]. Water–soluble ions make up the majority of the PM 2.5 samples, according to the component analysis of the samples, and they might be involved in inducing the production of ROS in cells.…”

Section: Resultsmentioning

confidence: 99%

The Cytotoxic Effects of Fine Particulate Matter (PM2.5) from Different Sources at the Air–Liquid Interface Exposure on A549 Cells

Yan,

Ge,

et al. 2023

Toxics

Self Cite

View full text Add to dashboard Cite

The health of humans has been negatively impacted by PM2.5 exposure, but the chemical composition and toxicity of PM2.5 might vary depending on its source. To investigate the toxic effects of particulate matter from different sources on lung epithelial cells (A549), PM2.5 samples were collected from residential, industrial, and transportation areas in Nanjing, China. The chemical composition of PM2.5 was analyzed, and toxicological experiments were conducted. The A549 cells were exposed using an air–liquid interface (ALI) exposure system, and the cytotoxic indicators of the cells were detected. The research results indicated that acute exposure to different sources of particulate matter at the air–liquid interface caused damage to the cells, induced the production of ROS, caused apoptosis, inflammatory damage, and DNA damage, with a dose–effect relationship. The content of heavy metals and PAHs in PM2.5 from the traffic source was relatively high, and the toxic effect of the traffic–source samples on the cells was higher than that of the industrial– and residential–source samples. The cytotoxicity of particulate matter was mostly associated with water–soluble ions, carbon components, heavy metals, PAHs, and endotoxin, based on the analysis of the Pearson correlation. Oxidative stress played an important role in PM2.5–induced biological toxicity.

show abstract

Section: Resultsmentioning

confidence: 99%