Ecotoxicity of CdTe quantum dots to freshwater mussels: Impacts on immune system, oxidative stress and genotoxicity

Gagné, François; Auclair, J. L.; Turcotte, Patrice; Fournier, Michel; Gagnon, Christian; Sauvé, Sébastien; Blaise, C.

doi:10.1016/j.aquatox.2007.11.013

Cited by 232 publications

(119 citation statements)

References 21 publications

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“…As a result, the majority of toxicological studies conducted with manufactured nanoparticles report the exposure dosage by using this same mass per volume ratio. However, numerous studies have demonstrated that nanoparticle toxic effects can be associated with particle size, shape, and total surface area, rather than total mass load [11,14,15,25]. In light of these results, it has been argued that mass concentrations in nanotoxicology studies will not always capture the true doseresponse relationship [3,4,25], and that exposure data should be reported in alternative dose metrics.…”

Section: Acute Toxicitymentioning

confidence: 95%

“…This toxic effect was exacerbated by exposure to air or ultraviolet (UV) light, which served to accelerate the oxidation process. Subsequent studies have further suggested that QD toxicity is a function of released Cd metal [10,11]. Alternatively, several studies have demonstrated QD toxicity independent of metals being released.…”

Section: Introductionmentioning

confidence: 94%

“…In addition, Hoshino et al [13] reported that the surface modification molecules can cause cytotoxicity. Finally, numerous studies have found a size-based toxicity, indicating differing toxicity behavior associated with QD core size [11,14,15]. These studies found that the smaller QDs had an elevated toxicity compared to the larger QDs.…”

Section: Introductionmentioning

confidence: 94%

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Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Pace

Lesher

Ranville

2010

Enviro Toxic and Chemistry

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The acute toxicity of polymer-coated CdSe/ZnS quantum dots (QDs) to Daphnia magna was investigated using 48-h exposure studies. The principal objective was to relate the toxicity of QDs to specific physical and chemical aspects of the QD. As such, two different CdSe core diameters, 2 nm QDs (green-emitting) and 5 nm QDs (red-emitting), and two different surface coatings, polyethylene oxide (PEO) and 11-mercaptoundecanoic acid (MUA) were studied. The QDs were characterized before and after the 48-h exposure using fluorescence, ultrafiltrations (3 kDa), and inductively coupled plasma-atomic emission spectrometry (ICP-AES) metal analysis. In addition, flow field flow fractionation-inductively coupled plasma-mass spectrometry (Fl FFF-ICP-MS) was used as a more extensive characterization technique to determine particle size and composition as well as identify other potential constituents in the QD solutions. The more stable QDs (PEO) were found to be less acutely toxic than the QDs with accelerated dissolution (MUA), suggesting QD stability has significant impact on the nanoparticles' short-term toxicity. The emergence of dissolved Cd(2+) in solution indicates that the toxicity of the MUA QDs is likely due to Cd poisoning, and a mass-based dose response occurred as a consequence of this mode of action. Alternatively, the PEO QDs caused acute toxicity without observed particle dissolution (i.e., no detectable metals were solubilized), suggesting an alternative mode of toxic action for these nanoparticles. Results of the present study suggest that using particle number, instead of mass, as a dose metric for the PEO QDs, produces markedly different conclusions, in that smaller core size does not equate to greater toxicity.

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Section: Acute Toxicitymentioning

confidence: 95%

Section: Introductionmentioning

confidence: 94%

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Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Pace

Lesher

Ranville

2010

Enviro Toxic and Chemistry

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“…This study strongly advocates in favor of the inclusion of epigenomic assays in the battery of tests routinely used in nanoparticles toxicological studies. QDs are ingested by freshwater mussels 36 and by rainbow trout. 30 …”

Section: Nanogenomic Effects Of Qdsmentioning

confidence: 99%

Quantum Dot Cytotoxicity and Ways To Reduce It

2012

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T he dramatic increase in the use of nanoparticles (NP) in industry and research has raised questions about the potential toxicity of such materials. Unfortunately, not enough is known about how the novel, technologically-attractive properties of NPs correlate with the interactions that may take place at the nano/bio interface. The academic, industrial, and regulatory communities are actively seeking answers to the growing concerns on the impact of nanotechnology on humans. In this Account we adopt quantum dots (QDs) as an illustrative example of the difficulties associated with the development of a rational sciencebased approach to nanotoxicology.The optical properties of QDs are far superior to those of organic dyes in terms of emission and absorption bandwidths, quantum yield, and resistance to photobleaching. Moreover, QDs may be decorated with targeting moieties or drugs and, therefore, are candidates for site-specific medical imaging and for drug delivery, for example in cancer treatment. Earlier this year researchers demonstrated that QD-based imaging using monkeys caused no adverse effects although QDs accumulated in lymph nodes, bone marrow, liver, and spleen for up to 3 months after injection. Such persistence of QDs in live animals does, however, raise concerns about the safety of using QDs both in the laboratory and in the clinic.Researchers anticipate that QDs will be increasingly used not only in clinical applications but also in various manufactured products. For example, QD-solar cells have emerged as viable contenders to complement or replace dye-sensitized solar cells; CdTe/CdS thin film cells have already captured approximately 10 percent of the global market, and in addition, QDs can serve as components of sensors and as emitting materials in LEDs. Given the clear indications that QDs will inevitably become components of a wide range of manufactured and consumer products, researchers and policy makers need to understand the possible health risks associated with exposure to QDs.In this Account, we initially review the known mechanisms by which QDs can damage cells, including oxidative stress elicited by reactive oxygen species (ROS). We discuss lesser-known impairments induced in cells by nanomolar to picomolar concentrations of QDs, which imply that cadmium-containing QDs can exert genotoxic, epigenetic, and metalloestrogenic effects. These observations strongly suggest that minute concentrations of QDs could be sufficient to cause long lasting, even transgenerational, effects. We also consider various modes by which humans could be exposed to QDs in their work or through the environment. Although considerable advances have been made in enhancing the stability and overall quality of QDs, over time they can partially degrade in the environment or in biological systems, and eventually cause small, but cumulative undesirable effects.A combination of toxicological, genetic, epigenetic and imaging approaches is required to create comprehensive guidelines for evaluating the nanotoxicity of nanomate...

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“…14 Literature data concerning their toxicity are rather conflicting because of 1) differences in physicochemical properties of each individual type of QDs (such as composition, size, surface charge, and functionalization), 2) lack of toxicologybased studies, and 3) variety of concentration tested. 15 Moreover, only a few studies have addressed the ecotoxicological effects of QDs in algae, 16 mussels, 17 crustaceans, 18 and fish. 19 The existence of diverse types of QDs presents a further challenge for toxicological evaluation because each individual type presents unique physicochemical properties, which will dominate its interactions with the biological system.…”

Section: Galdiero Et Almentioning

confidence: 99%

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

Galdiero¹,

Siciliano²,

Maselli³

et al. 2016

IJN

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This study attempts to evaluate the antimicrobial activity and the ecotoxicity of quantum dots (QDs) alone and coated with indolicidin. To meet this objective, we tested the level of antimicrobial activity on Gram-positive and Gram-negative bacteria, and we designed an ecotoxicological battery of test systems and indicators able to detect different effects using a variety of end points. The antibacterial activity was analyzed against Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 1025), Escherichia coli (ATCC 11229), and Klebsiella pneumoniae (ATCC 10031), and the results showed an improved germicidal action of QDs-Ind. Toxicity studies on Daphnia magna indicated a decrease in toxicity for QDs-Ind compared to QDs alone, lack of bioluminescence inhibition on Vibrio fisheri , and no mutations in Salmonella typhimurium TA 100 . The comet assay and oxidative stress experiments performed on D. magna showed a genotoxic and an oxidative damage with a dose–response trend. Indolicidin retained its activity when bound to QDs. We observed an enhanced activity for QDs-Ind. The presence of indolicidin on the surface of QDs was able to decrease its QDs toxicity.

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Ecotoxicity of CdTe quantum dots to freshwater mussels: Impacts on immune system, oxidative stress and genotoxicity

Cited by 232 publications

References 21 publications

Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Quantum Dot Cytotoxicity and Ways To Reduce It

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

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Ecotoxicity of CdTe quantum dots to freshwater mussels: Impacts on immune system, oxidative stress and genotoxicity

Cited by 232 publications

References 21 publications

Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Influence of stability on the acute toxicity of CdSe/ZnS nanocrystals to Daphnia magna

Quantum Dot Cytotoxicity and Ways To Reduce It

An integrated study on antimicrobial activity and ecotoxicity of&nbsp;quantum dots&nbsp;and&nbsp;quantum dots&nbsp;coated with the antimicrobial peptide indolicidin

Contact Info

Product

Resources

About

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin