Ecotoxicological effects of DBPs on freshwater phytoplankton communities in co-culture systems

Cui, Huijun; Zhu, Xiaoshan; Zhu, Yanjie; Huang, Yuxiong; Chen, Baiyang

doi:10.1016/j.jhazmat.2021.126679

Cited by 31 publications

(5 citation statements)

References 40 publications

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“…The VOCs in this study included disinfection byproducts (chloroform, bromodichloromethane, dibromochloromethane, and bromoform), methyl tert-butyl ether (MTBE), and other VOCs (tetrachloroethylene, benzene, 1,4-dichlorobenzene, ethylbenzene, o-xylene, styrene, trichloroethylene, toluene, m-p-xylene). Disinfection byproducts are formed when chlorine reacts with organic substances in water, and are commonly found in drinking and recreational water bodies ( 41 ). They exhibit cytotoxicity, mutagenicity, teratogenicity, and carcinogenicity.…”

Section: Discussionmentioning

confidence: 99%

Assessing volatile organic compounds exposure and chronic obstructive pulmonary diseases in US adults

Shen

et al. 2023

Front. Public Health

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BackgroundVolatile organic compounds (VOCs) are a large group of chemicals widely used in People’s Daily life. There is increasing evidence of the cumulative toxicity of VOCs. However, the association between VOCs and the risk of COPD has not been reported.ObjectiveWe comprehensively evaluated the association between VOCs and COPD.MethodsOur study included a total of 1,477 subjects from the National Health and Nutrition Examination Survey, including VOCs, COPD, and other variables in the average US population. Multiple regression models and smooth-curve fitting (penalty splines) were constructed to examine potential associations, and stratified analyses were used to identify high-risk groups.ResultsWe found a positive association between blood benzene and blood o-xylene concentrations and COPD risk and identified a concentration relationship between the two. That is, when the blood benzene and O-xylene concentrations reached 0.28 ng/mL and 0.08 ng/mL, respectively, the risk of COPD was the highest. In addition, we found that gender, age, and MET influence the relationship, especially in women, young people, and people with low MET.SignificanceThis study revealed that blood benzene and blood o-xylene were independently and positively correlated with COPD risk, suggesting that long-term exposure to benzene and O-xylene may cause pulmonary diseases, and providing a new standard of related blood VOCs concentration for the prevention of COPD.

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Section: Discussionmentioning

confidence: 99%

Assessing volatile organic compounds exposure and chronic obstructive pulmonary diseases in US adults

Shen

et al. 2023

Front. Public Health

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“…Authors indicated that intensified disinfection due to COVID-19 may lead to disturbances in the microalgal community. (Cui et al 2022 ) China Bacterial analysis of MRSA a infection in a hospital. A sharp increase in MRSA detection compared to 4 years pre-COVID-19 was observed in a mental health facility for elders in China.…”

Section: Fate and Transport Of Cbd S During And After Applicationmentioning

confidence: 99%

Environmental impacts of the widespread use of chlorine-based disinfectants during the COVID-19 pandemic

Parveen

Chowdhury

Goel

2022

Environ Sci Pollut Res

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Chlorinated disinfectants are widely used in hospitals, COVID-19 quarantine facilities, households, institutes, and public areas to combat the spread of the novel coronavirus as they are effective against viruses on various surfaces. Medical facilities have enhanced their routine disinfection of indoors, premises, and in-house sewage. Besides questioning the efficiency of these compounds in combating coronavirus, the impacts of these excessive disinfection efforts have not been discussed anywhere. The impacts of chlorine-based disinfectants on both environment and human health are reviewed in this paper. Chlorine in molecular and in compound forms is known to pose many health hazards. Hypochlorite addition to soil can increase chlorine/chloride concentration, which can be fatal to plant species if exposed. When chlorine compounds reach the sewer/drainage system and are exposed to aqueous media such as wastewater, many disinfection by-products (DBPs) can be formed depending on the concentrations of natural organic matter, inorganics, and anthropogenic pollutants present. Chlorination of hospital wastewater can also produce toxic drug-derived disinfection by-products. Many DBPs are carcinogenic to humans, and some of them are cytotoxic, genotoxic, and mutagenic. DBPs can be harmful to the flora and fauna of the receiving water body and may have adverse effects on microorganisms and plankton present in these ecosystems. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-021-18316-2.

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“…To date, about 100 DBPs had determined their potential acute aquatic toxicity on different aquatic organisms such as fish, crustacean, alga, etc. , It was worth mentioning that the available aquatic toxicity information of DBPs is limited to the acute toxicity up to now. Other potential adverse biological effects such as chronic toxicity and endocrine disrupting effects for the DBPs are relatively scarce.…”

Section: Introductionmentioning

confidence: 99%

Potential Disrupting Effects of Wastewater-Derived Disinfection Byproducts on Chinese Rare Minnow (Gobiocypris rarus) Transthyretin: An In Vitro and In Silico Study

Zhao

Yang

Liu

et al. 2023

Environ. Sci. Technol.

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The available information about whether wastewater-derived disinfection byproducts (DBPs) could elicit potential endocrine-related detrimental effects on aquatic organisms was scarce. Herein, the potential disrupting effects and underlying binding mechanism of 14 wastewater-derived aliphatic and aromatic DBPs and 12 other substances on Chinese rare minnow (Gobiocypris rarus) transthyretin (CrmTTR) were tested and revealed by in vitro and in silico methods. The amino acid sequences of CrmTTR were determined, and the recombinant CrmTTR with a molecular mass of 66.3 kDa was expressed and purified. In vitro assay results indicated that eight selected aromatic DBPs exhibited detectable CrmTTR disrupting ability. Meanwhile, six aliphatic DBPs were not CrmTTR binders. Molecular modeling results implied that hydrophobic hydrogen bonds and/or ionic pair interactions were non-negligible. Four binary classification models with high classification performance were constructed. A significant positive linear relationship was observed for the binding affinity data from CrmTTR and human TTR (n = 18, r = 0.922, p < 0.0001). However, the binding affinity for 13 out of 18 tested compounds with CrmTTR was higher than that with human TTR. All the results highlighted that some wastewater-derived DBPs may be potential disruptors on the aquatic organism endocrine system, and interspecies variation should not be neglected in future determination of the potential endocrine disrupting effects of wastewater-derived DBPs.

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Ecotoxicological effects of DBPs on freshwater phytoplankton communities in co-culture systems

Cited by 31 publications

References 40 publications

Assessing volatile organic compounds exposure and chronic obstructive pulmonary diseases in US adults

Assessing volatile organic compounds exposure and chronic obstructive pulmonary diseases in US adults

Environmental impacts of the widespread use of chlorine-based disinfectants during the COVID-19 pandemic

Potential Disrupting Effects of Wastewater-Derived Disinfection Byproducts on Chinese Rare Minnow (Gobiocypris rarus) Transthyretin: An In Vitro and In Silico Study

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