2006
DOI: 10.1016/j.neuroscience.2006.01.007
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Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

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Cited by 73 publications
(87 citation statements)
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References 39 publications
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“…However, the neurotoxic effects of the drugs of abuse may be enhanced by environmental factors, such as elevated temperature and loud noise (Gesi et al, 2004;Capela et al, 2006b). In contrast, stress manipulations (e.g.…”
Section: 4mentioning
confidence: 99%
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“…However, the neurotoxic effects of the drugs of abuse may be enhanced by environmental factors, such as elevated temperature and loud noise (Gesi et al, 2004;Capela et al, 2006b). In contrast, stress manipulations (e.g.…”
Section: 4mentioning
confidence: 99%
“…MDMA also induces apoptotic features in PC12 cells (Milhazes et al, 2006) and in rat cortical neurons (Capela et al, 2006b). MDMA-induced apoptosis in rat cortical neurons seems to be dependent on 5-HT 2A receptor activation (Capela et al, 2006b).…”
mentioning
confidence: 99%
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“…At or above this level, MDMA did induce macrophage death, consistent with literature reports that other cell types exposed to high micromolar, or low millimolar concentrations of MDMA, resulted in cell death in vitro. The drug induces apoptosis in primary, cortical neuronal cultures (Capela et al, 2007;Capela et al, 2006;Stumm et al, 1999), cerebellar granule cells (Jimenez et al, 2004), the neuronal cell line, PC12 (Milhazes et al, 2006), choriocarcinoma placental (JAR) cells (Simantov and Tauber, 1997), rat primary hepatocytes (Montiel-Duarte et al, 2004;Montiel-Duarte et al, 2002) and hepatic stellate cells (Montiel-Duarte et al, 2004). The cytotoxicity of MDMA and its metabolites is reported to be by an oxidative mechanism (Milhazes et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…We have initiated a survey of the expression of monoamine transporters and receptors in mouse macrophages, and find, intriguingly, expression of the mRNA for serotonin receptor Htr2a (unpublished results). Binding of MDMA to this receptor has recently been coupled to apoptosis in cortical neurons (Capela et al, 2007;Capela et al, 2006), and may account for both macrophage immunomodulation and, at higher concentrations, cell death. Further studies will need to be performed to ascertain if this macrophage receptor mediates these effects following drug exposure.…”
Section: Discussionmentioning
confidence: 99%