2016
DOI: 10.1016/j.ebiom.2016.10.020
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Ectopic Adipose Tissue Storage in the Left and the Right Renal Sinus is Asymmetric and Associated With Serum Kidney Injury Molecule-1 and Fibroblast Growth Factor-21 Levels Increase

Abstract: ObjectiveA potential mechanism by which obesity could promote hypertension and kidney diseases is through accumulation of adipose tissue in the renal sinus (RS). The aim of the study was to quantify RS and abdominal adipose tissue volumes and to evaluate serum kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21 association with different adipose tissue compartments.MethodsThe cross-sectional study included 280 and follow-up study-40 asymptomatic participants; aged 38.30 ± 4.10. For all study … Show more

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Cited by 37 publications
(38 citation statements)
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“…To assure and standardize RSF measurement at the same level for each patient, we selected the slice on which the renal artery entered the kidney. As two studies found an asymmetrical distribution of RSF (left kidney accumulates significantly more adipose tissue than the right kidney), Krievina et al recommend to assess the RSF in the left kidney rather than in the right one, stating that changes in RSF were more reliably observed this way [21,22]. For these reasons, we selected only the left kidney for further analyses.…”
Section: Renal Sinus Fat Mri Analysismentioning
confidence: 99%
See 1 more Smart Citation
“…To assure and standardize RSF measurement at the same level for each patient, we selected the slice on which the renal artery entered the kidney. As two studies found an asymmetrical distribution of RSF (left kidney accumulates significantly more adipose tissue than the right kidney), Krievina et al recommend to assess the RSF in the left kidney rather than in the right one, stating that changes in RSF were more reliably observed this way [21,22]. For these reasons, we selected only the left kidney for further analyses.…”
Section: Renal Sinus Fat Mri Analysismentioning
confidence: 99%
“…The same approach was used to validate singleslice representation of the total kidney (TK) area in these 15 patients. Furthermore, to exclude a systematic bias in RSF measurements due to different kidney sizes, we calculated the ratio of the RSF to total kidney size (RSF/TK), as done by others [10,22].…”
Section: Renal Sinus Fat Mri Analysismentioning
confidence: 99%
“…A cross-sectional study (36) found deposition of adipose tissue particularly into the left renal sinus, which was related with the VAT amount. However, reductions in VAT volume were not accompanied by reductions in renal sinus fat accumulation.…”
Section: Discussionmentioning
confidence: 99%
“…However, reductions in VAT volume were not accompanied by reductions in renal sinus fat accumulation. An increasing number of studies suggest, that renal sinus fat plays an important role in obesity-induced renal injury (37) which could be diagnosed and linked with early biomarkers of kidney injury (36).…”
Section: Discussionmentioning
confidence: 99%
“…In this issue of EBioMedicine, the study of Krievina et al takes a step in this direction by linking accumulation of adipose tissue in the RS with early diagnostic biomarkers of kidney injury (Krievina et al, in this issue). In this cross-sectional study, 280 asymptomatic middle-age participants were recruited, abdominal and RS adipose tissue were quantified by computed tomography, and serum levels of kidney injury molecule (sKIM)-1 and fibroblast growth factor (FGF)-21 were measured by standard procedures.…”
mentioning
confidence: 99%