Ectopic Lymphoid-Organ Development Occurs through Interleukin 7-Mediated Enhanced Survival of Lymphoid-Tissue-Inducer Cells

Meier, Dominik; Bornmann, Caroline; Chappaz, Stéphane; Schmutz, Sandrine; Otten, L.; Ceredig, Rhodri; Acha‐Orbea, Hans; Finke, Daniela

doi:10.1016/j.immuni.2007.04.009

Cited by 185 publications

(162 citation statements)

References 41 publications

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“…ILC2 and ILC3 are IL-7Ra + and these ILC subsets are strongly reduced in the absence of IL-7 (2). During both fetal and adult life, IL-7 signaling regulates the size of the LTi cell pool by promoting cell survival (60)(61)(62). In a similar fashion, IL-7 may sustain the homeostasis of ILC2 and NCR + ILC3.…”

Section: Factors Regulating Ilc Homeostasis and Functionmentioning

confidence: 99%

Taming the Beast within: Regulation of Innate Lymphoid Cell Homeostasis and Function

Santo²

2013

The Journal of Immunology

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Although substantial parallels have been made between transcription factor regulation of cytokine production by innate lymphoid cell (ILC) and Th cell subsets, we are still learning how ILC subsets are regulated during immune responses. Critical factors that promote ILC development and stimulate their effector functions have been identified, but mechanisms that control their homeostasis and downregulate their cytokine secretion remain poorly understood. In this review, we consider some of the potential positive and negative regulators of ILC homeostasis and function in physiological and pathological conditions.

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Section: Factors Regulating Ilc Homeostasis and Functionmentioning

confidence: 99%

Taming the Beast within: Regulation of Innate Lymphoid Cell Homeostasis and Function

Santo²

2013

The Journal of Immunology

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“…The adoptive transfer of adult CD4 + CD3 − LTi cells into Cxcr5 −/− mice induces the development of intestinal lymphoid tissues 31. Similarly, the increased availability of IL‐7 in transgenic mice has been associated with the LTi cell‐dependent development of additional Peyer's patches, caecal patches and de novo formation of ectopic lymphoid organs 32. A recent study has also shown that IL‐17 induces CXCL12 and iBALT development in response to Pseudomonas aeruginosa infection, where the main source of IL‐17 was γδ T cells (T γδ 17 cells) 33.…”

Section: Cellular Initiators Of Ectopic Lymphoneogenesismentioning

confidence: 99%

Ectopic lymphoid follicles: inducible centres for generating antigen‐specific immune responses within tissues

2015

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SummaryLymphoid neogenesis is traditionally viewed as a pre‐programmed process that promotes the formation of lymphoid organs during development. Here, the spatial organization of T and B cells in lymph nodes and spleen into discrete structures regulates antigen‐specific responses and adaptive immunity following immune challenge. However, lymphoid neogenesis is also triggered by chronic or persistent inflammation. Here, ectopic (or tertiary) lymphoid organs frequently develop in inflamed tissues as a response to infection, auto‐immunity, transplantation, cancer or environmental irritants. Although these structures affect local immune responses, the contribution of these lymphoid aggregates to the underlining pathology are highly context dependent and can elicit either protective or deleterious outcomes. Here we review the cellular and molecular mechanisms responsible for ectopic lymphoid neogenesis and consider the relevance of these structures in human disease.

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“…1A). We have previously shown that IL-7 is crucial for LTi cell (45) and LN development (31) and that, in addition to IL-7, other cytokines promote intestinal LTi cell and PP development (29,31). To investigate whether Flt3L has an influence on LTi cell development, we analyzed fetal and neonatal flt3l 2/2 mice and compared them with WT and Il7 2/2 mice.…”

Section: Flt3l Regulates Intestinal Lti Cell Numbers and Pp Developmentmentioning

confidence: 99%

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

Baerenwaldt

Burg

Kreuzaler

et al. 2016

The Journal of Immunology

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Flt3 ligand (Flt3L) promotes survival of lymphoid progenitors in the bone marrow and differentiation of dendritic cells (DCs), but its role in regulating innate lymphoid cells (ILCs) during fetal and adult life is not understood. By using Flt3L knockout and transgenic mice, we demonstrate that Flt3L controls ILC numbers by regulating the pool of α4β7− and α4β7+ lymphoid tissue inducer cell progenitors in the fetal liver and common lymphoid progenitors in the bone marrow. Deletion of flt3l severely reduced the number of fetal liver progenitors and lymphoid tissue inducer cells in the neonatal intestine, resulting in impaired development of Peyer’s patches. In the adult intestine, NK cells and group 2 and 3 ILCs were severely reduced. This effect occurred independently of DCs as ILC numbers were normal in mice in which DCs were constitutively deleted. Finally, we could show that administration of Flt3L increased the number of NKp46− group 3 ILCs in wild-type and even in Il7−/− mice, which generally have reduced numbers of ILCs. Taken together, Flt3L significantly contributes to ILC and Peyer’s patches development by targeting lymphoid progenitor cells during fetal and adult life.

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Ectopic Lymphoid-Organ Development Occurs through Interleukin 7-Mediated Enhanced Survival of Lymphoid-Tissue-Inducer Cells

Cited by 185 publications

References 41 publications

Taming the Beast within: Regulation of Innate Lymphoid Cell Homeostasis and Function

Taming the Beast within: Regulation of Innate Lymphoid Cell Homeostasis and Function

Ectopic lymphoid follicles: inducible centres for generating antigen‐specific immune responses within tissues

Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice

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