Ectopic pregnancies: current diagnostics and treatment

David, Matthias

doi:10.1007/s00129-023-05105-w

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…However, a clear predictor that can be used in place of β-hCG has not been obtained [3][4][5][6]. In addition to biomarkers, endometrial sampling can be used to diagnose EP and allows for the exclusion of intrauterine pregnancy [7]. Usually, β-hCG measurements are combined with US when diagnosing EP.…”

Section: Introductionmentioning

confidence: 99%

“…Methotrexate (MTX), used in the medical treatment of EP and considered the gold standard, is an antitumor drug with a molecular structure similar to folic acid [5]. The antitumor mechanism of MTX involves reversible competitive action on the Dihydrofolate Reductase enzyme, leading to the impairment of purine and pyrimidine rings synthesis and resulting in the inhibition of cell division [7]. Three MTX protocols (single, double, and multiple doses) are generally accepted for treating ectopic pregnancies [10].…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Tubal Rupture in Ectopic Pregnancy Using Methotrexate Treatment Protocols and Hematological Markers

Seyfettinoglu,

Adıguzel

2023

JCM

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Ectopic pregnancy is a pregnancy complication in which the embryo implants outside the uterine cavity. Although medical treatment is chosen first, sometimes a rupture may occur, and surgical treatment may be required. The parameters to predict rupture have been the subject of many studies. This study aimed to compare the efficacy of different methotrexate protocols in the treatment of ectopic pregnancy and determine the parameters and methotrexate treatment protocols that can predict the risk of rupture. A total of 128 patients diagnosed with ectopic pregnancy were included in this study. Patients were separated into three categories based on their treatment protocols. Regarding the occurrence of rupture, all three groups were compared. The hematological parameters and methotrexate treatment protocols were analyzed and compared between groups. The mean age was 31.9 years. Parity was significantly higher in patients who received multiple doses of methotrexate compared to the other groups. There were significant variations observed among the groups regarding parity, initial β-hCG values, hematocrit (HTC), and mean corpuscular volume (MCV) (p = 0.048, p < 0.001, p = 0.019, and p = 0.047, respectively). According to receiver operating characteristic analysis, neutrophil-to-lymphocyte ratio (NLR) levels were significantly associated with histopathologically confirmed tubal rupture (p < 0.05). NLR levels should be examined in ectopic pregnancy, and the possibility of rupture should be considered in cases with high NLR levels. The potential of NLR to predict ectopic pregnancy rupture should be explored in multicenter prospective studies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediction of Tubal Rupture in Ectopic Pregnancy Using Methotrexate Treatment Protocols and Hematological Markers

Seyfettinoglu,

Adıguzel

2023

JCM

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Klinisch-praktische Aspekte der Vorbereitung, Durchführung und Nachbetreuung beim Schwangerschaftsabbruch im ersten Trimenon

David

2024

Bundesgesundheitsbl

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ZusammenfassungIm Januar 2023 erschien die „S2k-Leitlinie zum Schwangerschaftsabbruch im ersten Trimenon“ der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. V. (AWMF), die vom Bundesministerium für Gesundheit (BMG) beauftragt wurde. Die Leitlinie befasst sich mit dem operativen und dem medikamentösen Schwangerschaftsabbruch nach Beratungsregelung, mit kriminologischer oder mit medizinischer Indikation in den ersten 14 Schwangerschaftswochen, bezogen auf die letzte Regelblutung. In diesem Übersichtsartikel werden, orientiert an dieser Leitlinie, die Abläufe beim medikamentösen und operativen Schwangerschaftsabbruch vor- sowie Vor- und Nachteile der beiden Methoden gegenübergestellt. Klinisch-praktische Aspekte der Vorbereitung und Durchführung, des Komplikationsmanagements und der unmittelbaren Nachbetreuung beim Schwangerschaftsabbruch werden präsentiert.

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Ectopic pregnancies: current diagnostics and treatment

Cited by 2 publications

References 16 publications

Prediction of Tubal Rupture in Ectopic Pregnancy Using Methotrexate Treatment Protocols and Hematological Markers

Prediction of Tubal Rupture in Ectopic Pregnancy Using Methotrexate Treatment Protocols and Hematological Markers

Klinisch-praktische Aspekte der Vorbereitung, Durchführung und Nachbetreuung beim Schwangerschaftsabbruch im ersten Trimenon

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