Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: Contacts with dopaminergic amacrine cells and melanopsin ganglion cells

Dumitrescu, O. N.; Pucci, Francesco; Wong, Kwoon Y.; Berson, David M.

doi:10.1002/cne.22158

Cited by 156 publications

(205 citation statements)

References 76 publications

Supporting

Mentioning

187

Contrasting

Order By: Relevance

“…Previous studies indicated that the functional IPL stratification schemes require amendment to include an accessory ON layer at the most distal portion of IPL stratum one, and perhaps throughout the entire OFF IPL (Dumitrescu et al, 2009;Hoshi et al, 2009). Our data are consistent with mixed ON-OFF processing throughout levels 0-45% of the IPL, consistent with bipolar cell stratification patterns in non-mammalians.…”

Section: On Cone Bipolar Cell Axonal Ribbons Throughout the Off Ipl Fsupporting

confidence: 87%

“…G-H). All of the above are consistent with M1-type ipRGCs (Dumitrescu et al, 2009;Graham et al, 2008;Hoshi et al, 2009). Henceforth, we shall simply refer to it as ipRGC 12208.…”

Section: Rod Bipolar Cell Axonal Ribbons Do Not Provide Accessory On supporting

confidence: 60%

“…As yet unknown targets exist in RC1, some of which which may be sparse TH1 axonal cell dendrites reported by Dumitrescu et al (2009) and Hoshi et al (2009). Additionally, preliminary data reveal that sixty-eight of ninety-seven (70.1%) measured ON cone bipolar cells contain one or more post-synaptic densitites (PSDs) to amacrine cell input in the OFF IPL, and recently discovered axonal cisterns appear in 55 of 113 (48.7%) ON cone bipolar cell axons measured thus far.…”

Section: Introductionmentioning

confidence: 97%

“…(Famiglietti et al, 1977;Famiglietti and Kolb, 1976;MacNeil et al, 2004;Wässle et al, 2009;Werblin and Dowling, 1969). Nevertheless, examples of nominal cone bipolar cells breaking the mammalian IPL stratification rules were recently reported (Anderson et al, 2011a;Dumitrescu et al, 2009;Hoshi et al, 2009). Type 6, and possibly type 7 or 8, ON cone bipolar cells in mouse, and calbindin-positive layer 4/5 stratifying ON cone bipolar cells in rabbit, have been demonstrated targeting tyrosine hydrdoxylasepositive cells (TH1s), M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) and bsdGCs in stratum one of the IPL (Dumitrescu et al, 2009;Hoshi et al, 2009), thus representing an accessory ON input to the OFF IPL layers.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, examples of nominal cone bipolar cells breaking the mammalian IPL stratification rules were recently reported (Anderson et al, 2011a;Dumitrescu et al, 2009;Hoshi et al, 2009). Type 6, and possibly type 7 or 8, ON cone bipolar cells in mouse, and calbindin-positive layer 4/5 stratifying ON cone bipolar cells in rabbit, have been demonstrated targeting tyrosine hydrdoxylasepositive cells (TH1s), M1-type intrinsically photosensitive retinal ganglion cells (ipRGCs) and bsdGCs in stratum one of the IPL (Dumitrescu et al, 2009;Hoshi et al, 2009), thus representing an accessory ON input to the OFF IPL layers. These ribbon contacts appear in two varieties: en passant, occurring inside the main bipolar cell descending axons, and branched, occurring from small processes that branch off the main descending axon ( Figure 2).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina

Lauritzen

Anderson

Jones

et al. 2013

J of Comparative Neurology

View full text Add to dashboard Cite

Analysis of the rabbit retinal connectome RC1 reveals that the division between the ON and OFF inner plexiform layer (IPL) is not structurally absolute. ON cone bipolar cells make non-canonical axonal synapses onto specific targets and receive amacrine cell synapses in the nominal OFF layer, creating novel motifs, including inhibitory crossover networks. Automated transmission electron microscope (ATEM) imaging, molecular tagging, tracing, and rendering of ≈ 400 bipolar cells reveals axonal ribbons in 36% of ON cone bipolar cells, throughout the OFF IPL. The targets include GABA-positive amacrine cells (γACs), glycine-positive amacrine cells (GACs) and ganglion cells. Most ON cone bipolar cell axonal contacts target GACs driven by OFF cone bipolar cells, forming new architectures for generating ON-OFF amacrine cells. Many of these ON-OFF GACs target ON cone bipolar cell axons, ON γACs and/or ON-OFF ganglion cells, representing widespread mechanisms for OFF to ON crossover inhibition. Other targets include OFF γACs presynaptic to OFF bipolar cells, forming γAC-mediated crossover motifs. ON cone bipolar cell axonal ribbons drive bistratified ON-OFF ganglion cells in the OFF layer and provide ON drive to polarity-appropriate targets such as bistratified diving ganglion cells (bsdGCs). The targeting precision of ON cone bipolar cell axonal synapses shows that this drive incidence is necessarily a joint distribution of cone bipolar cell axonal frequency and target cell trajectories through a given volume of the OFF layer. Such joint distribution sampling is likely common when targets are sparser than sources and when sources are coupled, as are ON cone bipolar cells.

show abstract

Section: On Cone Bipolar Cell Axonal Ribbons Throughout the Off Ipl Fsupporting

confidence: 87%

“…G-H). All of the above are consistent with M1-type ipRGCs (Dumitrescu et al, 2009;Graham et al, 2008;Hoshi et al, 2009). Henceforth, we shall simply refer to it as ipRGC 12208.…”

Section: Rod Bipolar Cell Axonal Ribbons Do Not Provide Accessory On supporting

confidence: 60%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina

Lauritzen

Anderson

Jones

et al. 2013

J of Comparative Neurology

View full text Add to dashboard Cite

show abstract

Emerging data on the use of anti‐tumor necrosis factor‐alpha medications in pregnancy

Chambers

Johnson

2012

Birth Defects Research

View full text Add to dashboard Cite

Anti-tumor necrosis factor (TNF) α medications are used for the treatment of a number of autoimmune diseases. Evaluation of pregnancy safety for these medications is complicated by the contribution of the underlying maternal disease to adverse pregnancy outcomes, such as preterm delivery and reduced birth weight. Placental transport of these medications is thought to be minimal in the first trimester, thereby providing some reassurance regarding theoretical risks for congenital malformations. Available human exposure data are sparse; however, to date there has been no convincing evidence to support an increased risk for a specific pattern of major congenital malformations with any of the drugs in this group for which some data is currently available. As a result of the improvement of symptoms during pregnancy in some women with autoimmune diseases, it may be possible to discontinue treatment before or shortly after conception. However, in some cases the benefits of treatment and concerns for disease flares in pregnancy have warranted continued treatment during pregnancy. Because of the relatively long half-life of these medications, and theoretical concerns for immune compromise of the infant following exposure in the latter two trimesters, some clinicians recommend discontinuation of treatment in the third trimester to avoid potentially prolonged infant exposure in the postpartum period. Currently ongoing controlled cohort studies for some of the TNF blocker medications will help to provide more definitive answers for clinicians and patients.

show abstract

Cell‐type‐specific localization of protocadherin β16 at AMPA and AMPA/kainate receptor‐containing synapses in the primate retina

Puller

Haverkamp

2010

J of Comparative Neurology

View full text Add to dashboard Cite

Protocadherins (Pcdhs) are thought to be key features of cell-type-specific synapse formation. Here we analyzed the expression pattern of Pcdh subunit β16 (β16) in the primate retina by applying antibodies against β16, different subunits of ionotropic glutamate receptors (GluRs), and cell-type-specific markers as well as by coimmunoprecipitation and Western blots. Immunocytochemical localization was analyzed by confocal microscopy and preembedding electron microscopy. In the outer plexiform layer (OPL) H1, but not H2, horizontal cells expressed β16 as revealed by the strong reduction of β16 at short-wavelength-sensitive cones. β16 colocalized with the GluR subunits GluR2-4 at horizontal cell dendritic tips and with GluR2-4 and GluR6/7 at the desmosome-like junctions. At the latter, these AMPA and kainate receptor subunits were found to be clustered within single synaptic hot spots. Additionally, β16-labeled dendritic tips of OFF cone bipolar cells appeared in triad-associated positions at the cone pedicle base, pointing to β16 expression by OFF midget or DB3 bipolar cells. In the inner plexiform layer, β16 was localized also postsynaptically at most of the glutamatergic synapses. Overall, we provide evidence for a cell-type-specific localization of β16 together with GluRs at defined postsynaptic sites and a coexistence of AMPA and kainate receptors within single synaptic hot spots. This study supports the hypothesis that β16 plays an important role in the formation and/or stabilization of specific glutamatergic synapses, whereas our in vivo protein biochemical results argue against the existence of protein complexes formed by β16 and GluRs.

show abstract

Ectopic retinal ON bipolar cell synapses in the OFF inner plexiform layer: Contacts with dopaminergic amacrine cells and melanopsin ganglion cells

Cited by 156 publications

References 76 publications

ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina

ON cone bipolar cell axonal synapses in the OFF inner plexiform layer of the rabbit retina

Emerging data on the use of anti‐tumor necrosis factor‐alpha medications in pregnancy

Cell‐type‐specific localization of protocadherin β16 at AMPA and AMPA/kainate receptor‐containing synapses in the primate retina

Contact Info

Product

Resources

About