Ectopic Thyroid Carcinoma with Metastases in a Beagle Dog

Stephens, L. Clifton; Saunders, William J.; Jaenke, Roger S.

doi:10.1177/030098588201900612

Cited by 23 publications

(23 citation statements)

References 6 publications

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“…3 Neoplasms at the heart base were chemodectomas or ectopic parathyroid or thyroid gland carcinomas. 10,16,22,24 Lymphomas or epithelial thymomas were also identified in this location. Intracavitary heart neoplasms were hemangiosarcomas, chemodectomas, or rhabdomyomas.…”

Section: Discussionmentioning

confidence: 77%

Intrapericardial Neoplasia in Dogs

Girard

Hélie

Odin³

1999

J VET Diagn Invest

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Abstract.A retrospective study was conducted from 1,919 necropsies of dogs, and 52 cases were selected on the basis of primary or metastatic neoplasia in the pericardium, the heart base, or the myocardium. Primary intrapericardial neoplasms were more frequent than intrapericardial metastases. Hemangiosarcomas were the most frequent primary neoplasms, followed by chemodectomas. Lymphomas were the most frequent metastatic neoplasms, followed by fibrosarcomas and rhabdomyosarcomas. Other neoplasms, either primary or metastatic, occurred rarely.Neoplasms affecting the pericardium, the heart base or the myocardium are infrequent in the dog, representing only a small proportion of necropsy cases. 6,27 Hemangiosarcomas 4,13,27 and chemodectomas 2,4,27,28 are the most frequently observed. Other mesenchymal and epithelial tumors have been sporadically reported. 1,4,7,8,11,12,14,15,17,18,20,23,[25][26][27] Ratios of primary intrapericardial versus metastatic neoplasms and of metastatic mesenchymatous versus epithelial neoplasms are unknown.A 6-year retrospective study was done to determine the incidence of primary or metastatic intrapericardial neoplasia in the dog. The relative frequency of primary versus metastatic and metastatic mesenchymatous versus epithelial neoplasms affecting the pericardium, the heart base, and the pericardium were also investigated. Materials and methodsSelection of cases. Necropsies were performed on 1,919 dogs over a 6-yr period (January 1990 to December 1995 at the Faculty of Veterinary Medicine, University of Montreal. Neoplasms were diagnosed in 184 cases, and 52 of these were selected for study based on their intrapericardial localization.Light microscopy. Tissues were fixed in buffered 10% formalin, embedded in paraffin, sectioned at 5 m, and stained with hematoxylin, phloxin, and saffron (HPS). Giemsa, periodic acid-Schiff, phosphotungstic acid-hematoxylin, Gridley's reticulin and/or Grimelius stains were used on selected sections.Immunoperoxidase. Monoclonal antibodies a were used to detect the presence of desmin, vimentin, alpha-smooth muscle actin (SMA), myoglobin, and cytokeratin and polyclonal antibodies were used for calcitonin, thyroglobulin, muramidase, alpha-1 antitrypsin, kappa-lambda light chains, a and factor VIII-related antigen b on selected neoplasms to confirm the diagnosis. Sections were cut at 5 m and mounted on Received for publication May 14, 1997.slides precoated with poly-D-lysine. Sections were stained by the avidin-biotin complex method using standard reagents. c Sections were deparaffinized in successive xylene immersions, dehydrated through graded ethanols, and rehydrated in distilled water. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide diluted in methanol. Sections were incubated overnight at 4 C with appropriate primary antibody in a humidified chamber, followed by incubation at room temperature in a humidified chamber with appropriate biotinylated antibodies. Sections were then covered with freshly prepared avidin-biotin-peroxidase solu...

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Section: Discussionmentioning

confidence: 77%

Intrapericardial Neoplasia in Dogs

Girard

Hélie

Odin³

1999

J VET Diagn Invest

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“…This finding is consistent with the existence of only sporadic literature reports describing these tumors. 7,11,26,40,44 Nevertheless, ectopic thyroid tissue within the mediastinum is reported to occur frequently in the dog. 83 The majority of heart tumors in people are reported to be metastatic.…”

Section: Discussionmentioning

confidence: 99%

“…Only sporadic cases of cardiac myxoma have been reported in dogs. 19,20,24,26 Occasional cases of ectopic thyroid or parathyroid tumors at the heart base, 7,11,26,40,44 pericardial mesotheliomas, 61,[70][71][72] or other neoplasms [8][9][10]24,[26][27][28][29]35,36,39,[73][74][75][76] also have been reported. Some histologic types of cardiac tumors have been associated with certain breeds of dogs.…”

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confidence: 99%

Cardiac Tumors in Dogs: 1982–1995

Ware

Hopper

1999

Veterinary Internal Medicne

208

185

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A Veterinary Medical Database search from 1982 to 1995 identified 1,383 dogs with tumors of the heart from a total population of 729,265 dogs (0.19% incidence). Hemangiosarcoma (HSA) was the most common cardiac tumor identified. In the subset of dogs with specific histologic diagnoses, the number with HSA was almost 10-fold that of the 2nd most common tumor, aortic body tumor. Primary heart tumors were more common than cardiac metastases. When biologic behavior was noted, most heart tumors were classified as malignant. Cardiac tumors (excluding lymphoma) occurred most often in dogs between the ages of 7 and 15 years. In very old dogs (>15 years), the frequency of cardiac tumors was the same or lower than that of the youngest age group. Tumors occurred with similar frequency in males and females, but the relative risk for spayed females was >4 times that for intact females. For HSA, spayed females had >5 times greater relative risk than did intact females. The risk for castrated males was slightly greater than that for intact males, which had 2.4 times the relative risk of intact females. Thus, neutering appeared to increase the risk of cardiac tumor in both sexes. Intact females were least likely to develop a cardiac tumor, whereas spayed females were most likely to develop a tumor. Twelve breeds had greater than average risk of developing a cardiac tumor, whereas 17 had lower risk.

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“…The frequency of hemangiosarcomas is almost 10 times that of chemodectomas [5]. Less common heart tumors include granular cell tumors [6], chondrosarcomas [7], osteosarcomas [8], fibromas [9], fibrosarcomas [10,11], cardiac lipomas [12], malignant mesenchymal tumors [13], lymphomas [14,15], rhabdomyosarcomas [16,17], neurofibromas [18], angiolipomas [19], myxomas [20][21][22][23], right atrial myxosarcomas [21,24,25], ectopic thyroid carcinomas [26][27][28], and pericardial mesothelioma ( Figure 18-1) [1,5].…”

Section: Types Of Tumors and Prevalencementioning

confidence: 99%

“…Other tumors in this area, less frequently encountered, are ectopic thyroid carcinomas [27] and lymphomas [5,14]. There are differences of echogenicity (homogenous or heterogenous tissue, degree of echogenicity), site of origin, dimensions, shape, location, contour (smooth or irregular), mobility, infiltration, single or multiple lesions, unilocular or multilocular structures, and growth type, which can help to differentiate these types of tumors.…”

Section: Heart Base Tumorsmentioning

confidence: 99%

Cardiac Tumors

Bussadori¹

2015

Clinical Echocardiography of the Dog and Cat

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Ectopic Thyroid Carcinoma with Metastases in a Beagle Dog

Cited by 23 publications

References 6 publications

Intrapericardial Neoplasia in Dogs

Intrapericardial Neoplasia in Dogs

Cardiac Tumors in Dogs: 1982–1995

Cardiac Tumors

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