Ectosomes released by human neutrophils are specialized functional units

Hess, Christoph; Sadallah, Salima; Hefti, Andreas; Landmann, Régine; Schifferdi, J.A.

doi:10.1016/s0161-5890(98)90627-7

Cited by 136 publications

(206 citation statements)

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“…PMN-derived ectosomes have been characterized relatively extensively (Gasser and Schifferli, 2005;Gasser et al, 2003;Hess et al, 1999). The formation of ectosomes in PMNs have been observed using electron microscopy.…”

Section: Cell-cell Communication Via Ectosomesmentioning

confidence: 99%

Cell-Cell Communication Via Extracellular Membrane Vesicles and Its Role in the Immune Response

Hwang

2013

Molecules and Cells

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The host immune response involves a variety of cell types, including specialized immune and non-immune cells. The delicate coordination among these cells via close communication is central for the proper operation of immune system. Cell-cell communication is mediated by a complex network that includes soluble factors such as cytokines, chemokines, and metabolites exported from cells, as well as membrane-bound receptors and their ligands. Cell-cell communication is also mediated by membrane vesicles (e.g., exosomes, ectosomes), which are either shed by distant cells or exchanged by cells that are making direct contact. Intercellular communication via extracellular membrane vesicles has drawn much attention recently, as they have been shown to carry various biomolecules that modulate the activities of recipient cells. In this review, I will discuss current views on cell-cell communication via extra-cellular membrane vesicles, especially shedded membrane vesicles, and their effects on the control of the immune system.

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Section: Cell-cell Communication Via Ectosomesmentioning

confidence: 99%

Cell-Cell Communication Via Extracellular Membrane Vesicles and Its Role in the Immune Response

Hwang

2013

Molecules and Cells

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“…Most of the data on PMN-derived EVs (called in these studies ectosomes) come from the laboratory of Dr. Schifferli [26,[34][35][36]39,40,45,[93][94][95][96]. They characterized the size and surface properties of EVs released upon fMLP-stimulation and came to the conclusion that both the in vitro and the in vivo generated EVs are right-side out [39,45].…”

Section: Role Of Pmn-derived Vesicles In Communicationmentioning

confidence: 99%

“…They characterized the size and surface properties of EVs released upon fMLP-stimulation and came to the conclusion that both the in vitro and the in vivo generated EVs are right-side out [39,45]. Further, they demonstrated that PMN-derived EVs increased the secretion of the anti-inflammatory cytokine TGF-β1 from monocytes, whereas the stimulated release of IL-8, IL-10 and TNFα was decreased [40].…”

Section: Role Of Pmn-derived Vesicles In Communicationmentioning

confidence: 99%

Changing world of neutrophils

Tímár

Lörincz

Ligeti

2013

Pflugers Arch - Eur J Physiol

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“…Stimulus-induced shedding of plasma membrane-derived microvesicles-which bear distinctive complements of membrane markers-has been described in both hematopoietic cell types (platelets, DCs, and neutrophils) and non-hematopoietic cell types (epithelial cells, cancer cells, and neurons) [25][26][27][28][29]. The size of these released vesicles ranges between 100 nm and 1 μm in diameter which distinguishes them from the 1-4-μm apoptotic bodies containing fragmented DNA derived from damaged cells, and from the 30-80-nm exosomes (discussed below) derived from the intraluminal vesicles of endosomal multivesicular bodies (MVB).…”

Section: P2x7r Regulation Of Plasma Membrane Microvesicle Releasementioning

confidence: 99%

“…Small membrane vesicles released into the circulation from activated platelets are described in the literature as microparticles (MP); these have major roles in blood coagulation by providing a large surface area for the assembly of clotting factors that bind to the exposed phosphatidylserine of the released MPs [30,31]. Activated human neutrophils release "ectosomes" that exhibit anti-inflammatory activity and mediate inhibition of DC maturation from cultured blood monocytes [26,27,32]. Particles secreted from the basolateral membranes of various epithelial cells during tissue development are called "argosomes" due to their involvement in the transfer of developmental morphogens between cells and the maintenance of morphogen gradients [33].…”

Section: P2x7r Regulation Of Plasma Membrane Microvesicle Releasementioning

confidence: 99%

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

Dubyak

2009

Purinergic Signalling

108

101

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Activation of the P2X7 receptor (P2X7R) triggers a remarkably diverse array of membrane trafficking responses in leukocytes and epithelial cells. These responses result in altered profiles of cell surface lipid and protein composition that can modulate the direct interactions of P2X7R-expressing cells with other cell types in the circulation, in blood vessels, at epithelial barriers, or within sites of immune and inflammatory activation. Additionally, these responses can result in the release of bioactive proteins, lipids, and large membrane complexes into extracellular compartments for remote communication between P2X7R-expressing cells and other cells that amplify or modulate inflammation, immunity, and responses to tissue damages. This review will discuss P2X7R-mediated effects on membrane composition and trafficking in the plasma membrane (PM) and intracellular organelles, as well as actions of P2X7R in controlling various modes of nonclassical secretion. It will review P2X7R regulation of: (1) phosphatidylserine distribution in the PM outer leaflet; (2) shedding of PM surface proteins; (3) release of PM-derived microvesicles or microparticles; (4) PM blebbing; (5) cell-cell fusion resulting in formation of multinucleate cells; (6) phagosome maturation and fusion with lysosomes; (7) permeability of endosomes with internalized pathogen-associated molecular patterns; (8) permeability/integrity of mitochondria; (9) exocytosis of secretory lysosomes; and (10) release of exosomes from multivesicular bodies.

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Ectosomes released by human neutrophils are specialized functional units

Cited by 136 publications

References 0 publications

Cell-Cell Communication Via Extracellular Membrane Vesicles and Its Role in the Immune Response

Cell-Cell Communication Via Extracellular Membrane Vesicles and Its Role in the Immune Response

Changing world of neutrophils

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

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