Eculizumab therapy and complement regulation in a case of resistant catastrophic antiphospholipid syndrome
Rachel Frederick,
Luigi Zolio,
Evange Romas
et al.
Abstract:Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening form of antiphospholipid syndrome characterised by diffuse arterial and venous thrombosis, in the presence of positive antiphospholipid antibodies. The multiple sites of thrombosis in small, medium and large vessels progress to multiorgan failure, accounting for the high mortality rate associated with CAPS. Unregulated complement activation is increasingly recognised as critical to the pathogenesis of CAPS. Early diagnosis is essential to init… Show more
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