Edge illumination X-ray phase tomography of multi-material samples using a single-image phase retrieval algorithm

Zamir, Anna; Diémoz, Paul C.; Vittoria, Fabio A.; Hagen, Charlotte K.; Endrizzi, Marco; Olivo, Alessandro

doi:10.1364/oe.25.011984

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…An appropriate method would be able to reconstruct sharp images for any sample composition, including samples with strong absorbers like bone. First steps have been taken in this regard, e.g., we have developed an extension to the single-frame phase retrieval that can accommodate multiple material interfaces [24]. However, that method requires that the final image is "spliced" from individual reconstructions, which is not straightforward on complex samples.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging

et al. 2019

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Purpose: To enable a preliminary assessment of the suitability of edge illumination (EI) x-ray phase contrast (XPC) micro x-ray computed tomography (micro-CT) to preclinical imaging. Specifically, to understand how different acquisition schemes and their combination with dedicated data processing affect contrast-to-noise ratio (CNR) and spatial resolution, while providing control over scan time and radiation dose delivery. Procedures: Deceased mice (n = 3) were scanned with an EI XPC micro-CT setup operated under different settings, leading to scan times between 18 h and 13 min. For the shortest scan, the entrance dose was measured with a calibrated PTW 23344 ion chamber. Different data processing methods were applied, retrieving either separate attenuation and phase images, or hybrid (combined attenuation and phase) images. A quantitative comparison was performed based on CNR and spatial resolution measurements for a soft tissue interface. Results: All phase-based images have led to a higher CNR for the considered soft tissue interface than the attenuation image, independent of scan time. The best relative CNR (a sixfold increase) was observed in one of the hybrid images. Spatial resolution was found to be connected to scan time, with a resolution of approximately 20 μm and 60 μm achieved for the longest and shortest scans, respectively. An entrance dose of approximately 300 mGy was estimated for the scan performed within 13 min. Conclusions: Despite their preliminary nature, our results suggest that EI XPC bears potential for enhancing the utility of preclinical micro-CT, and, pending further research and development, could ultimately become a valuable technique in this field.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging

et al. 2019

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“…Future work will be dedicated to the extension of the method to the case of multi-material samples (Beltran et al, 2010;Zamir et al, 2017). Finally, the developed method can be directly generalized to two-dimensional XGI (Sato et al, 2011;Morimoto et al, 2015) and also applied to phase tomography (Ruiz-Yaniz et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Single-image phase retrieval for hard X-ray grating interferometry

Wang

Ren

Shi

et al. 2019

J Synchrotron Radiat

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A single‐image method is proposed for quantitative phase retrieval in hard X‐ray grating interferometry. This novel method assumes a quasi‐homogeneous sample, with a constant ratio between the real and imaginary parts of its complex refractive index. The method is first theoretically derived and presented, and then validated by synchrotron radiation experiments. Compared with the phase‐stepping method, the presented approach abandons grating scanning and multiple image acquisition, and is therefore advantageous in terms of its simplified acquisition procedure and reduced data‐collection times, which are especially important for applications such as in vivo imaging and phase tomography. Moreover, the sample's phase image, instead of its first derivative, is directly retrieved. In particular, the stripe artifacts encountered in the integrated phase images are significantly suppressed. The improved quality of the retrieved phase images can be beneficial for image interpretation and subsequent processing. Owing to its requirement for a single image and its robustness against noise, the present method is expected to find use in potential investigations in diverse applications.

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“…In addition, even if the presence of a single homogeneous material is assumed in its derivation, Paganin's phase retrieval can be adapted to strongly heterogeneous samples via multimaterial approaches [28,29]. This work makes use of the aforementioned theoretical background and reports on a microscale computedtomography (μ-CT) monochromatic PBI setup based on a high-power rotating-anode x-ray generator suitable for biological samples on the millimeter scale.…”

Section: Introductionmentioning

confidence: 99%

Monochromatic Propagation-Based Phase-Contrast Microscale Computed-Tomography System with a Rotating-Anode Source

et al. 2019

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We present an experimental setup for monochromatic propagation-based x-ray phase-contrast imaging based on a conventional rotating-copper-anode source, capable of an integrated flux up to 10 8 photons/s at 8 keV. In our study, the system is characterized in terms of spatial coherence, resolution, contrast sensitivity, and stability. Its quantitativeness is demonstrated by comparing theoretical predictions with experimental data on simple wire phantoms both in planar and computerized-tomography-scan geometries. Application to two biological samples of medical interest shows the potential for bioimaging on the millimeter scale with spatial resolution of the order of 10 μm and contrast resolution below 1%. All the scans are performed within laboratory-compatible exposure times, from 10 min to a few hours, and trade-offs between scan time and image quality are discussed.

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Edge illumination X-ray phase tomography of multi-material samples using a single-image phase retrieval algorithm

Cited by 17 publications

References 36 publications

A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging

A Preliminary Investigation into the Use of Edge Illumination X-ray Phase Contrast Micro-CT for Preclinical Imaging

Single-image phase retrieval for hard X-ray grating interferometry

Monochromatic Propagation-Based Phase-Contrast Microscale Computed-Tomography System with a Rotating-Anode Source

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