Editorial comment on “Oral immunotherapy as a curative treatment for food‐allergic preschool children: Current evidence and potential underlying mechanisms”

Arasi, Stefania; Ebisawa, Motohiro; Eigenmann, Philippe; Dinardo, Giulio

doi:10.1111/pai.14071

Pediatric Allergy Immunology

2024

DOI: 10.1111/pai.14071

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Editorial comment on “Oral immunotherapy as a curative treatment for food‐allergic preschool children: Current evidence and potential underlying mechanisms”

Stefania Arasi,

Motohiro Ebisawa,

Philippe Eigenmann

et al.

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2024

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Cited by 3 publications

References 7 publications

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Role of biologics in severe food allergy

Dinardo,

Cafarotti,

Fierro

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review This review examine the dynamic landscape of food allergy treatment within the context of emerging biologics. Our purpose is to comprehensively evaluate the potential benefits, challenges, and transformative impact associated with the utilization of biologics in comparison to conventional therapeutic modalities. Recent findings This document synthesizes recent scientific investigations to various biologics, such as omalizumab, ligelizumab, dupilumab, and tezepelumab, providing a nuanced understanding of their roles in oral immunotherapy, rapid desensitization, and overall food allergy management. Recent studies and clinical trials highlight the impact of anti-IgE treatment on food allergies, revealing critical findings such as dose-related efficacy, facilitation of rapid desensitization in peanut allergies, and the sustained positive outcomes observed in individuals with multifood allergies. Summary The use of biologics presents a groundbreaking approach in the treatment of food allergies. The multifaceted action of these agents, along with their potential to overcome the challenges associated with traditional therapies, marks a significant advancement. Despite the persisting challenges of economic constraints and the need for further safety studies, biologics offer a promising avenue for improving the quality of life for individuals with food allergies. Ongoing research and collaborative efforts are imperative to fully realize the transformative potential inherent in these emerging therapeutic frontiers.

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Role of biologics in severe food allergy

Dinardo,

Cafarotti,

Fierro

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

Self Cite

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Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation

Fierro,

Mazzuca,

Urbani

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review The purpose of this review is to provide an overview of the perspectives regarding precautionary allergen labelling (PAL) of prepackaged foods following the consultation conducted by the Food and Agriculture Organization (FAO) and the WHO. Recent findings The FAO/WHO consultation provided a comprehensive assessment of the current status and practices of PAL implementation worldwide. One of the key findings highlighted by the Expert Committee was the need for improvement in existing PAL systems. It was noted that many countries lacked uniformity in PAL practices, leading to inconsistencies in labelling and potentially misleading information for consumers. Furthermore, the consultation emphasized the importance of PAL being risk-based, taking into account both the amount and frequency of unintended allergen presence (UAP) in food products. Summary The FAO/WHO consultation shed light on various perspectives and challenges associated with PAL of prepackaged foods. Key findings emphasized the need for improvement in existing PAL systems, including the adoption of a risk-based approach, standardized regulations, and enhanced transparency. Moving forward, collaborative efforts between regulatory agencies, food manufacturers, and consumer advocacy groups will be essential in developing effective PAL strategies that prioritize consumer safety and well being.

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Transplant-Acquired Food Allergy in Children

Indolfi,

Klain,

Dinardo

et al. 2024

Nutrients

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Background: Organ transplantation in children is a vital procedure for those with end-stage organ failure, but it has been linked to the development of post-transplant allergies, especially food allergies. This phenomenon, known as transplant-acquired food allergy (TAFA), is becoming increasingly recognized, though its mechanisms remain under investigation. Pediatric transplant recipients often require lifelong immunosuppressive therapy to prevent graft rejection, which can alter immune function and heighten the risk of allergic reactions. Our review aimed to gather the latest evidence on TAFA. Methods: We conducted a PubMed search from 25 June to 5 July 2024, using specific search terms, identifying 143 articles. After screening, 36 studies were included: 24 retrospective studies, 1 prospective study, 2 cross-sectional researches, and 9 case reports/series. Results: Most studies focused on liver transplants in children. The prevalence of food allergies ranged from 3.3% to 54.3%. Tacrolimus, alongside corticosteroids, was the most commonly used immunosuppressive therapy. In addition to food allergies, some patients developed atopic dermatitis, asthma, and rhinitis. Allergic symptoms typically emerged within a year post-transplant, with common allergens including milk, eggs, fish, nuts, soy, wheat, and shellfish. Both IgE-mediated and non-IgE-mediated reactions were observed, with treatment often involving the removal of offending foods and the use of adrenaline when necessary. Conclusions: Consistent immunological monitoring, such as skin prick tests and IgE level assessments, is essential for early detection and management of allergies in these patients. Understanding the link between transplantation and allergy development is crucial for improving long-term outcomes for pediatric transplant recipients.

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Editorial comment on “Oral immunotherapy as a curative treatment for food‐allergic preschool children: Current evidence and potential underlying mechanisms”

Cited by 3 publications

References 7 publications

Role of biologics in severe food allergy

Role of biologics in severe food allergy

Perspectives in precautionary allergen labelling of prepackaged foods after the FAO/WHO consultation

Transplant-Acquired Food Allergy in Children

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