Editorial Comment to Expanding the limits of nephron‐sparing surgery: Surgical technique and mid‐term outcomes of purely off‐clamp robotic partial nephrectomy for totally endophytic renal tumors

Pandolfo, Savio Domenico; Loizzo, Davide; Autorino, Riccardo

doi:10.1111/iju.14788

Cited by 5 publications

(2 citation statements)

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“…Renal cell carcinoma (RCC) is the 6th most frequently diagnosed cancer in men and the 10th in women, representing the 3rd most frequent genitourinary malignancy worldwide and the 13th most common cause of cancer death worldwide [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

Aveta

Cilio

Contieri

et al. 2023

IJMS

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MicroRNAs (miRNAs) are emerging as biomarkers for the detection and prognosis of cancers due to their inherent stability and resilience. To summarize the evidence regarding the role of urinary miRNAs (umiRNAs) in the detection, prognosis, and therapy of genitourinary cancers, we performed a systematic review of the most important scientific databases using the following keywords: (urinary miRNA) AND (prostate cancer); (urinary miRNA) AND (bladder cancer); (urinary miRNA) AND (renal cancer); (urinary miRNA) AND (testicular cancer); (urinary miRNA) AND (urothelial cancer). Of all, 1364 articles were screened. Only original studies in the English language on human specimens were considered for inclusion in our systematic review. Thus, a convenient sample of 60 original articles was identified. UmiRNAs are up- or downregulated in prostate cancer and may serve as potential non-invasive molecular biomarkers. Several umiRNAs have been identified as diagnostic biomarkers of urothelial carcinoma and bladder cancer (BC), allowing us to discriminate malignant from nonmalignant forms of hematuria. UmiRNAs could serve as therapeutic targets or recurrence markers of non-muscle-invasive BC and could predict the aggressivity and prognosis of muscle-invasive BC. In renal cell carcinoma, miRNAs have been identified as predictors of tumor detection, aggressiveness, and progression to metastasis. UmiRNAs could play an important role in the diagnosis, prognosis, and therapy of urological cancers.

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Section: Resultsmentioning

confidence: 99%

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

Aveta

Cilio

Contieri

et al. 2023

IJMS

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“…With the spread of this concept and improvements in surgical technology, the application of PN for renal tumors has been extended to more challenging cases, including ERTs ( 1 ). Although several authors have reported their successful experiences and beneficial results ( 19 – 21 ), the evidence in support of PN as a standard is weak. Due to the highly complex branching anatomical structure, it is challenging to remove deep endophytic tumors and suture incised renal parenchyma and hilar structures without increasing perioperative complications; this requires considerable anatomical knowledge and technical skill ( 2 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis

Xiong

Jiang

et al. 2022

Front. Oncol.

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PurposeThe study aimed to compare operative, functional, and oncological outcomes between partial nephrectomy (PN) and radical nephrectomy (RN) for entophytic renal tumors (ERTs) by propensity score matching (PSM) analysis.MethodsA total of 228 patients with ERTs who underwent PN or RN between August 2014 and December 2021 were assessed. A PSM in a 1:1 ratio was conducted to balance the differences between groups. Perioperative characteristics, renal functional, and oncological outcomes were compared between groups. Univariate and multivariate logistic and Cox proportional hazard regression analyses were used to determine the predictors of functional and survival outcomes.ResultsAfter PSM, 136 cases were matched to the PN group (n = 68) and the RN group (n = 68). Patients who underwent RN had shorter OT, less EBL, and lower high-grade complications (all p <0.05) relative to those who underwent PN. However, better perseveration of renal function was observed in the PN group, which was reflected in 48-h postoperative AKI (44.1% vs. 70.6%, p = 0.002), 1-year postoperative 90% eGFR preservation (45.6% vs. 22.1%, p = 0.004), and new-onset CKD Stage ≥III at last follow-up (2.9% vs. 29.4%, p <0.001). RN was the independent factor of short-term (OR, 2.812; 95% CI, 1.369–5.778; p = 0.005) and long-term renal function decline (OR, 10.242; 95% CI, 2.175–48.240; p = 0.003). Furthermore, PN resulted in a better OS and similar PFS and CSS as compared to RN (p = 0.042, 0.15, and 0.21, respectively). RN (OR, 7.361; 95% CI, 1.143–47.423; p = 0.036) and pT3 stage (OR, 4.241; 95% CI, 1.079–16.664; p = 0.039) were independent predictors of overall mortality.ConclusionAmong patients with ERTs, although the PN group showed a higher incidence of high-grade complications than RN, when technically feasible and with experienced surgeons, PN is recommended for better preservation of renal function, longer OS, and similar oncological outcomes.

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A systematic review of robot-assisted partial nephrectomy outcomes for advanced indications: Large tumors (cT2-T3), solitary kidney, completely endophytic, hilar, recurrent, and multiple renal tumors

Pandolfo,

Cerrato,

et al. 2023

Asian Journal of Urology

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Editorial Comment to Expanding the limits of nephron‐sparing surgery: Surgical technique and mid‐term outcomes of purely off‐clamp robotic partial nephrectomy for totally endophytic renal tumors

Cited by 5 publications

References 5 publications

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

Partial Nephrectomy Versus Radical Nephrectomy for Endophytic Renal Tumors: Comparison of Operative, Functional, and Oncological Outcomes by Propensity Score Matching Analysis

A systematic review of robot-assisted partial nephrectomy outcomes for advanced indications: Large tumors (cT2-T3), solitary kidney, completely endophytic, hilar, recurrent, and multiple renal tumors

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