Editorial Commentary: Stem Cell Exosomes Can Promote Healing and Muscle Function After Rotator Cuff Repair

Davies, M.R.Q.

doi:10.1016/j.arthro.2022.02.018

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Much of this effort has been focused on preclinical models thus far in an attempt to better understand the optimal parameters (99-103), but a number of clinical trials are evaluating the potential of the use of biologics to enhance healing outcomes. These studies include the use of PRP (104), the potential of stem cells (105-108), and more recently, the use of EV or exosomes (109)(110)(111).…”

Section: Biologics and Repair Of Tendon Rupturesmentioning

confidence: 99%

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Hart

Ahmed²,

Ackermann³

2023

Front. Sports Act. Living

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Tendons are dense connective tissues of the musculoskeletal system that link bones with muscles to foster mobility. They have complex structures and exist in varying biomechanical, metabolic and biological environments. In addition, tendon composition and mechanical properties can change over the lifespan as an individual ages. Many tendons function in high stress conditions with a low vascular and neuronal supply, conditions often leading to development of chronic tendinopathies, and in some cases, overt rupture of the tissues. Given their essential nature for human mobility and navigation through the environment, the effective repair and regeneration of different tendons after injury or damage is critical for quality of life, and for elite athletes, the return to sport participation at a high level. However, for mainly unknown reasons, the outcomes following injury are not always successful and lead to functional compromise and risk for re-injury. Thus, there is a need to identify those patients who are at risk for developing tendon problems, as well those at risk for poor outcomes after injury and to design interventions to improve outcomes after injury or rupture to specific tendons. This review will discuss recent advances in the identification of biomarkers prognostic for successful and less successful outcomes after tendon injury, and the mechanistic implications of such biomarkers, as well as the potential for specific biologic interventions to enhance outcomes to improve both quality of life and a return to participation in sports. In addition, the implication of these biomarkers for clinical trial design is discussed, as is the issue of whether such biomarkers for successful healing of one tendon can be extended to all tendons or are valid only for tendons in specific biomechanical and biological environments. As maintaining an active lifestyle is critical for health, the successful implementation of these advances will benefit the large number of individuals at risk.

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Section: Biologics and Repair Of Tendon Rupturesmentioning

confidence: 99%

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Hart

Ahmed²,

Ackermann³

2023

Front. Sports Act. Living

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“…Recent research has demonstrated that MuSC-derived exosomes (MuSC-Exo) exhibit proregenerative properties in tissue regeneration and may serve as effective treatments for several diseases, including corneal epithelium, stroma, and cartilage regeneration. [10,12,13] However, the efficacy of MuSC-Exo in addressing skeletal muscle atrophy and fibrosis remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Satellite Cell‐Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis

Liu,

Yuan,

Liu

et al. 2024

Advanced Biology

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Skeletal muscle atrophy coincides with extensive fibrous tissue hyperplasia in muscle‐atrophied patients, and fibrous tissue plays a vital role in skeletal muscle function and hinders muscle fiber regeneration. However, effective drugs to manage skeletal muscle atrophy and fibrosis remain elusive. This study isolated and characterized exosomes derived from skeletal muscle satellite cells (MuSC‐Exo). The study investigated their effects on denervated skeletal muscle atrophy and fibrosis in Sprague Dawley (SD) rats via intramuscular injection. MuSC‐Exo demonstrated the potential to alleviate skeletal muscle atrophy and fibrosis. The underlying mechanism using single‐cell RNA sequencing data and functional analysis are analyzed. Mechanistic studies reveal close associations between fibroblasts and myoblasts, with the transforming growth factor β1 (TGF‐β1)‐Smad3‐Pax7 axis governing fibroblast activation in atrophic skeletal muscle. MuSC‐Exo intervention inhibited the TGF‐β1/Smad3 pathway and improved muscle atrophy and fibrosis. In conclusion, MuSC‐Exo‐based therapy may represent a novel strategy to alleviate skeletal muscle atrophy and reduce excessive fibrotic tissue by targeting Pax7 through the TGF‐β1/Smad3 pathway.

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Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing

Wang,

Guan,

Zhang

et al. 2024

Journal of Orthopaedic Translation

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Editorial Commentary: Stem Cell Exosomes Can Promote Healing and Muscle Function After Rotator Cuff Repair

Cited by 3 publications

References 13 publications

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Satellite Cell‐Derived Exosomes: A Novel Approach to Alleviate Skeletal Muscle Atrophy and Fibrosis

Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing

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