Editorial: Complexity of tumor microenvironment: A major culprit in cancer development, volume II

Bukhari, Ihtisham; Zhang, Yuanwei; Thorne, Rick F.; Mi, Yang

doi:10.3389/fendo.2022.1126778

Cited by 1 publication

(1 citation statement)

References 41 publications

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“…The fact that a tumor is not a simple group of highly proliferating cells with an abnormal phenotype, but a multicellular structure which functions at an impressively organized level [ 12 , 54 , 55 ], leads to the conclusion that any in vitro data are of limited value until they are confirmed by adequate in vivo screening. The greatest advantage of the syngeneic model relates to preserved constituents and activities in the TME, and the whole-body support in combating disease, including systemic immunity and non-immune cell activities relevant to the therapeutic response [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Dual Role of Alchemilla vulgaris L. Extract in Breast Cancer Regression: Reestablishment of Effective Immune Response

Jelača,

Jovanovic,

Bovan

et al. 2024

Pharmaceuticals

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Ethnomedicinal records have long mentioned the historical usage of Alchemilla vulgaris L. in folk medicine, particularly for the treatment of gynecological issues. Building on this ethnomedicinal knowledge regarding female illnesses, the aim of this research was to evaluate the impact of ethanolic extract of A. vulgaris on mouse breast cancer cells (4T1) in vitro and in vivo, in addition to its effect on the immune compartment in the tumor microenvironment. Behind viability decrease of 4T1 cells induced by treatment with A. vulgaris extract was strong inhibition of cell proliferation accompanied by caspase-dependent apoptosis and autophagic cell death. Observed changes in 4T1 cell culture after treatment were well orchestrated and led to a reduction in metastatic potential through weakened adhesion, invasion, migration, and colony-forming abilities in vitro. Enhanced intracellular production of reactive oxygen and nitrogen species promoted by the treatment might interfere with all the observed effects. Apart from the direct effect on tumor cells, the A. vulgaris extract significantly reduced tumor growth in the solid orthotropic mammary carcinoma model through restitution of efficient local and systemic immune response reflected in enhanced antigen-presenting potential of dendritic cells (DCs) as well as the extent and activity of effector T cells.

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