Editorial: Corticospinal Excitability in Patients With Multiple Sclerosis

Chalah, Moussa A.; Palm, Ulrich; Ayache, Samar S.

doi:10.3389/fneur.2020.635612

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Using navigated transcranial magnetic stimulation (TMS) in probing corticospinal excitability as a marker of functional integrity of the primary motor cortex (M1), corticospinal axonal pathway, and peripheral signaling function to target muscles could help in further understanding the underlying pathophysiological mechanisms of MS. Recent findings proposed that applying TMS as an adjuvant para-clinical instrument could help to identify biomarkers of the MS disease [8], serving as a biomarker of MS disability [9]. An association between the pathophysiological mechanisms of MS (demyelination and axonal loss) and TMS measures (e.g., low amplitudes and prolonged latencies of motor evoked potentials (MEP), increased resting motor threshold (RMT), and increased central motor conduction time) have been reported [6].…”

Section: Multiple Sclerosis (Ms) Is An Inflammatory Autoimmune-mediat...mentioning

confidence: 99%

Transcranial Magnetic Stimulation Measures, Pyramidal Score on Expanded Disability Status Scale and Magnetic Resonance Imaging of Corticospinal Tract in Multiple Sclerosis

Rogić Vidaković,

Ćurković Katić,

Pavelin

et al. 2023

Bioengineering

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Probing the cortic ospinal tract integrity by transcranial magnetic stimulation (TMS) could help to understand the neurophysiological correlations of multiple sclerosis (MS) symptoms. Therefore, the study objective was, first, to investigate TMS measures (resting motor threshold-RMT, motor evoked potential (MEP) latency, and amplitude) of corticospinal tract integrity in people with relapsing-remitting MS (pwMS). Then, the study examined the conformity of TMS measures with clinical disease-related (Expanded Disability Status Scale—EDSS) and magnetic resonance imaging (MRI) results (lesion count) in pwMS. The e-field navigated TMS, MRI, and EDSS data were collected in 23 pwMS and compared to non-clinical samples. The results show that pwMS differed from non-clinical samples in MEP latency for upper and lower extremity muscles. Also, pwMS with altered MEP latency (prolonged or absent MEP response) had higher EDSS, general and pyramidal, functional scores than pwMS with normal MEP latency finding. Furthermore, the RMT intensity for lower extremity muscles was predictive of EDSS functional pyramidal scores. TMS/MEP latency findings classified pwMS as the same as EDSS functional pyramidal scores in 70–83% of cases and were similar to the MRI results, corresponding to EDSS functional pyramidal scores in 57–65% of cases. PwMS with altered MEP latency differed from pwMS with normal MEP latency in the total number of lesions in the brain corticospinal and cervical corticospinal tract. The study provides preliminary results on the correspondence of MRI and TMS corticospinal tract evaluation results with EDSS functional pyramidal score results in MS.

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Section: Multiple Sclerosis (Ms) Is An Inflammatory Autoimmune-mediat...mentioning

confidence: 99%

Transcranial Magnetic Stimulation Measures, Pyramidal Score on Expanded Disability Status Scale and Magnetic Resonance Imaging of Corticospinal Tract in Multiple Sclerosis

Rogić Vidaković,

Ćurković Katić,

Pavelin

et al. 2023

Bioengineering

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“…Multimodal Eps, such as somatosensory evoked potentials (SEPs), visual evoked potentials (VEPs), and motor evoked potentials (MEPs), recorded as baseline (at diagnosis), have been shown to correlate with EDSS [ 12 ]. Recent findings suggest the likely application of TMS as a subclinical MEP test that could represent a biomarker of the degree of MS disability [ 13 , 14 ]. Current data suggest a connection between the pathophysiological mechanisms of MS (demyelination and loss of axons) and TMS neurophysiological measures (e.g., lower amplitudes and longer latencies of MEP responses from upper and lower limb muscles, elevated resting motor threshold (RMT), and changes in specific neurophysiological measures of excitation and inhibition) [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Motor Evoked Potentials in Multiple Sclerosis

Šoda

Pavelin

Vujović

et al. 2023

Sensors

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Transcranial magnetic stimulation (TMS) is a noninvasive technique mainly used for the assessment of corticospinal tract integrity and excitability of the primary motor cortices. Motor evoked potentials (MEPs) play a pivotal role in TMS studies. TMS clinical guidelines, concerning the use and interpretation of MEPs in diagnosing and monitoring corticospinal tract integrity in people with multiple sclerosis (pwMS), were established almost ten years ago and refer mainly to the use of TMS implementation; this comprises the magnetic stimulator connected to a standard EMG unit, with the positioning of the coil performed by using the external landmarks on the head. The aim of the present work was to conduct a narrative literature review on the MEP assessment and outcome measures in clinical and research settings, assessed by TMS Methodological characteristics of different TMS system implementations (TMS without navigation, line-navigated TMS and e-field-navigated TMS); these were discussed in the context of mapping the corticospinal tract integrity in MS. An MEP assessment of two case reports, by using an e-field-navigated TMS, was presented; the results of the correspondence between the e-field-navigated TMS with MRI, and the EDSS classifications were presented. Practical and technical guiding principles for the improvement of TMS studies in MEP assessment for MS are discussed, suggesting the use of e-field TMS assessment in the sense that it can improve the accuracy of corticospinal tract integrity testing by providing a more objective correspondence of the neurophysiological (e-field-navigated TMS) and clinical (Expanded Disability Status Scale—EDSS) classifications.

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“…Motor-evoked potentials (MEPs) represent neurophysiological measures of signal conduction in the CNS in vivo. Examining corticospinal excitability as a marker of functional integrity of the primary motor cortex (M1) and the corticospinal pathway using e-filed navigated transcranial magnetic stimulation (TMS) by assessing MEP could elucidate the underlying pathophysiological mechanisms of MS [16,17,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation

Režić Mužinić,

Markotić,

Pavelin

et al. 2023

Biomedicines

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Expression of CD40 and CD192 markers in different monocyte subpopulations has been reported to be altered in people with MS (pwMS). Also, functional connectivity of the corticospinal motor system pathway alterations has been proved by transcranial magnetic stimulation (TMS). The study objective was to investigate the expression of CD40 and CD192 in classical (CD14++CD16−), intermediate CD14++CD16+ and non-classical (CD14+CD16++) blood monocyte subpopulations in pwMS, undergoing neurophysiological TMS assessment of the corticospinal tract integrity by recording motor-evoked potentials (MEPs). Radiological examination on lesion detection with MRI was performed for 23 patients with relapsing–remitting MS treated with teriflunomide. Then, immunological analysis was conducted on peripheral blood samples collected from the patients and 10 healthy controls (HC). The blood samples were incubated with anti-human CD14, CD16, CD40 and CD192 antibodies. Next, pwMS underwent neurological testing of functional disability (EDSS) and TMS assessment with recording MEPs from upper and lower extremity muscles. The results show that in comparison to HC subjects, both pwMS with normal and altered MEP findings (prolonged MEP latency or absent MEP response) had significantly decreased surface receptor expression measured (MFIs) of CD192 and increased CD40 MFI in classical monocytes, and significantly increased percentages of classical and total monocytes positive for CD40. Knowing CD40’s pro-inflammatory action, and CD192 as a molecule that enables the passing of monocytes into the brain, decreased CD192 in classical monocytes could represent a beneficial anti-inflammatory parameter.

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Editorial: Corticospinal Excitability in Patients With Multiple Sclerosis

Cited by 7 publications

References 6 publications

Transcranial Magnetic Stimulation Measures, Pyramidal Score on Expanded Disability Status Scale and Magnetic Resonance Imaging of Corticospinal Tract in Multiple Sclerosis

Transcranial Magnetic Stimulation Measures, Pyramidal Score on Expanded Disability Status Scale and Magnetic Resonance Imaging of Corticospinal Tract in Multiple Sclerosis

Assessment of Motor Evoked Potentials in Multiple Sclerosis

Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation

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