Editorial: Dosimetry Study in Photodynamic Therapy for Diagnosis, Precision Treatment and Treatment Evaluation

Liu, Hui

doi:10.3389/fphy.2020.588484

Front. Phys.

2020

DOI: 10.3389/fphy.2020.588484

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Editorial: Dosimetry Study in Photodynamic Therapy for Diagnosis, Precision Treatment and Treatment Evaluation

Hui Liu

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2022

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Cited by 2 publications

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Implementation and uniformity calibration of LED array for photodynamic therapy

Wang

Xiong

et al. 2022

J. Innov. Opt. Health Sci.

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Irradiance uniformity is an important parameter for a Photodynamic Therapy (PDT) device. The calibration and verification of a LED array light source based on computer vision technology were implemented and carried out. First, the correlation coefficients between the pulse width modulate value and the irradiance were calibrated. Then, the correction of the actual light center and divergence angle were solved by image processing to reduce errors from each LED lens. Finally, uniformity was optimized according to the irradiance formula of the Lambertian source. The lowest coefficients of variation of irradiance were 4.87% in a [Formula: see text] area and 3.55% in a [Formula: see text] area within the depth range of 8–12[Formula: see text]cm when the expected irradiance was 100[Formula: see text]mW/cm2. This finding indicated that the light source can achieve a more uniform illumination and provide a better therapeutic effect for the PDT of port-wine stains.

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Implementation and uniformity calibration of LED array for photodynamic therapy

Wang

Xiong

et al. 2022

J. Innov. Opt. Health Sci.

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Three-dimensional image-guided topical photodynamic therapy system with light dosimetry dynamic planning and monitoring

Wang¹,

Teng²,

Xiong³

et al. 2022

Biomed. Opt. Express

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Photodynamic therapy (PDT) has shown significant potential for skin disease treatment. As a key element, light is critical to influencing its treatment outcome, and light dosimetry is an issue of much concern for researchers. However, because of three-dimensional irregularity in shape and patient’s movement during the therapy, irradiance hardly keeps uniform on the lesion and flux measurement remains a challenge. In this work, we report the development of a three-dimensional image-guided PDT system, and the method of dynamic irradiance planning and flux monitoring for lesions in different poses. This system comprises a three-dimensional camera for monitoring patients’ movement during therapy, a computer for data analysis and processing, and a homemade LED array for forming uniform irradiance on lesions. Simulations on lesions of the face and arm show that the proposed system significantly increases effective therapy area, enhances irradiance uniformity, is able to visualize flux on the lesion, and reduces risks of burns during PDT. The developed PDT system is promising for optimizing procedures of PDT and providing better treatment outcomes by delivering controllable irradiance and flux on lesions even when a patient is moving.

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Editorial: Dosimetry Study in Photodynamic Therapy for Diagnosis, Precision Treatment and Treatment Evaluation

Cited by 2 publications

References 17 publications

Implementation and uniformity calibration of LED array for photodynamic therapy

Implementation and uniformity calibration of LED array for photodynamic therapy

Three-dimensional image-guided topical photodynamic therapy system with light dosimetry dynamic planning and monitoring

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