Editorial: Emerging Technologies Powering Rare and Neglected Disease Diagnosis and Theraphy Development

Liu, Zhichao; Hatim, Qais; Thakkar, Shraddha; Roberts, Ruth; Shi, Tieliu

doi:10.3389/fphar.2022.877401

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…These innovations encompass diverse advancements, ranging from artificial intelligence (AI), machine learning, and deep learning to nanomedicine, 3D printing, and smart devices. Their integration is pivotal in enhancing diagnostic accuracy, tailoring personalized treatment approaches, and improving patient outcomes [46][47][48][49][50]. In cancer diagnostics, novel technologies like liquid biopsies, digital biopsies, and nanoparticle-based drug delivery systems are reshaping traditional management approaches.…”

Section: Emerging Technologies In Diagnosis and Treatmentmentioning

confidence: 99%

Navigating Abdominal Volvulus: A Comprehensive Review of Management Strategies

Chauhan,

Shinde,

Jain

2024

Cureus

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Abdominal volvulus represents a critical condition characterized by the abnormal twisting of the GI tract, potentially leading to obstruction and vascular compromise. Prompt recognition and appropriate management are essential to prevent complications and improve patient outcomes. This comprehensive review examines the anatomy, pathophysiology, clinical presentation, and diagnostic evaluation of, and management strategies for abdominal volvulus. Non-operative techniques, including detorsion and decompression, as well as surgical interventions, such as laparoscopic and open approaches, are discussed. Additionally, the importance of multidisciplinary collaboration and postoperative care is emphasized. Despite significant advancements, unresolved issues remain, necessitating further research to refine diagnostic and therapeutic approaches. Future directions, including exploring emerging technologies, offer promise for enhancing the management of this challenging condition. Overall, this review provides clinicians with valuable insights into the optimal management of abdominal volvulus, aiming to improve patient outcomes and enhance clinical practice.

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Section: Emerging Technologies In Diagnosis and Treatmentmentioning

confidence: 99%

Navigating Abdominal Volvulus: A Comprehensive Review of Management Strategies

Chauhan,

Shinde,

Jain

2024

Cureus

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“…Obstacles such as incomplete knowledge of natural history make it difficult to understand the ecology and pathogenesis of rare and neglected diseases. Emerging technologies, including NGS and dPCR, provide opportunities to accelerate the diagnosis and development of treatments for these diseases [60,61]. The application of NGS in Leishmania isolates has allowed the characterization of populations through the identification and analysis of variations.…”

Section: Uses Of Nsg and Dpcr In The Diagnosis Of The Causal Agents O...mentioning

confidence: 99%

Metabarcoding and Digital PCR (dPCR): Application in the Study of Neglected Tropical Diseases

Lagunes-Castro¹,

López‐Monteon²,

Guzmán-Gómez³

et al. 2023

New Advances in Neglected Tropical Diseases

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neglected tropical diseases such as Chagas disease, dengue, Zika, chikungunya, and malaria cause millions of deaths each year and they are caused by a variety of pathogens whose diagnosis is very limited or subject to conventional testing, making a treatment less accessible, accurate and timely diagnosis for choosing their treatments. Traditional methods for pathogen detection have not been able to meet the growing need for diagnosis and control. The incorporation of new technologies such as next-generation sequencing (NGS) and digital PCR (dPCR) represent a better diagnostic possibility due to their ability to absolutely quantify pathogens with high selectivity and precision. Our planet is currently experiencing environmental changes of an unprecedented magnitude and rate, including climate change, globalized pollution, biodiversity loss, and land use changes, so neglected diseases require a comprehensive understanding of the ecology of vectors in the different eco-epidemiological contexts, as well as of the transmission cycles of pathogens and their transmission dynamics. In this sense, NGS and dPCR open a new panorama for a better understanding of these diseases with the aim of proposing new programs for their care.

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