EDITORIAL. Field change, clonality, and early epithelial cancer: possible lessons from p53

Ogden, Graham S.; Hall, Peter A.

doi:10.1002/(sici)1096-9896(199702)181:2<127::aid-path737>3.0.co;2-4

Cited by 21 publications

(6 citation statements)

References 18 publications

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“…It has also been reported that p53 immunodetection in normal looking areas of tumour bearing epithelium, in pre-neoplastic and pre-invasive lesions, suggests that p53 accumulation represents both an early event in oral carcinogenesis and a marker of field cancerisation. 29,30 Out of the two positive cases of dysplasia, in one sample, the staining was confined to the basal and parabasal layers, but in other, suprabasal staining pattern was observed. A recent study by Cruz et al 31 reported that p53 expression in the suprabasal layers in the oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 97%

p53 Expression in Oral cancer: A study of 50 cases

Ghanghoria

Shukla

2015

J Pathol Nep

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Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion. Materials and methods:Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion. Conclusion:Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.

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Section: Discussionmentioning

confidence: 97%

p53 Expression in Oral cancer: A study of 50 cases

Ghanghoria

Shukla

2015

J Pathol Nep

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“…The concept of field cancerization was proposed half a century ago to provide an explanation for the frequently observed multifocality and high recurrence rate of head and neck cancers, and considerable new evidence now suggests that this hypothesis will stand the test of time (43–45). For TP53, W aridel et al .…”

Section: Discussionmentioning

confidence: 99%

Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in Iceland

Ögmundsdóttir

Hilmarsdóttir

Ástvaldsdóttir

et al. 2002

European J Oral Sciences

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Oral squamous cell carcinoma (OSCC) is a world-wide health problem. In addition to external exposure (smoking and alcohol), certain oral lesions may increase the risk of oral cancer (e.g. leukoplakia, erythroplakia, and oral lichen planus). TP53 has been implicated in OSCC, but there are limited studies of mutations in premalignant oral lesions. In this study, 55 samples from OSCC, 47 from hyperkeratotic (HK) oral mucosa, clinically diagnosed as white patches, 48 samples from oral lichen planus (OLP), and 12 biopsies from normal oral mucosa were studied immunohistochemically for expression of TP53 protein. From all the carcinoma samples and selected non-malignant samples showing moderate or strong TP53 protein expression, malignant cells or TP53-positive nuclei were microdissected and screened for mutations in exons 5-8 by constant denaturation gel electrophoresis. Moderate to strong TP53 protein staining was seen in 56% of OSCC, 32% of OLP but only in 13% of HK. All OLP samples showed a characteristic pattern of positive nuclei confined to the basal layer, whereas TP53 staining was seen in suprabasal nuclei in HK. Mutation rate was 11 out of 52 for OSCC, three out of 20 tested for HK and, remarkably, nine out 27 tested for OLP. There was no correlation between TP53 protein staining and TP53 mutations. No associations were found with anatomical sites or disease progression. The unexpectedly high mutation rate of OLP might explain the premalignant potential of this lesion.

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“…It has a much longer half‐life than the wild‐type protein, leading to its accumulation in the cell, which can be detected by using specific antibodies. Detection of this biomarker plays an important role in early identification of damaged cells for cancer localization and may contribute to the early diagnosis of esophageal tumors 9 , 12 , 21 , 22 …”

Section: Discussionmentioning

confidence: 99%

p53 protein in esophageal mucosa of individuals at high risk of squamous cell carcinoma of the esophagus

Fagundes

Mello

Tollens

et al. 2001

Diseases of the Esophagus

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Squamous cell carcinoma of the esophagus (SCCE) is diagnosed late and carries a poor prognosis. Biomarkers such as p53 protein expression may be present in the esophageal mucosa long before esophageal symptoms or lesions appear and may point toward early diagnosis. Asymptomatic subjects at high risk for SCEE (consumption of more than 80 g of ethanol and 10 cigarettes/day for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa, and expression of p53 protein was compared with conventional histologic findings. In 182 subjects studied, p53 protein was expressed in a stepwise fashion according to the severity of the histologic findings: normal mucosa (12/103 or 11.7%), mild chronic esophagitis (6/43 or 14%), moderate chronic esophagitis (4/18 or 22.2%), severe chronic esophagitis (1/3 or 33.3%), low-grade dysplasia (4/11 or 36.4%), high-grade dysplasia (2/2 or 100%), and squamous cell carcinoma (2/2 or 100%) (P=0.00025). The odds ratio and confidence intervals were calculated by logistic regression, with multivariate adjustment for potentially confounding variables. The risk for p53 expression was twofold for moderate and severe chronic esophagitis and 10-fold for dysplasia and cancer (P=0.001). p53 protein was expressed not only in cancerous lesions, high-grade and low-grade dysplasia, as expected, but also in mucosa considered normal or with chronic esophagitis using conventional histology. Smokers and alcohol drinkers with normal mucosa or chronic esophagitis that express p53 protein may represent an unrecognized subgroup of individuals that may benefit from surveillance. Follow-up studies of these asymptomatic subjects and molecular analysis of the p53 gene are needed to clarify this point.

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EDITORIAL. Field change, clonality, and early epithelial cancer: possible lessons from p53

Cited by 21 publications

References 18 publications

p53 Expression in Oral cancer: A study of 50 cases

p53 Expression in Oral cancer: A study of 50 cases

Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in Iceland

p53 protein in esophageal mucosa of individuals at high risk of squamous cell carcinoma of the esophagus

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