Editorial for Special Issue “Multidrug-Resistant Pathogens”

Koulenti, Despoina; Fragkou, Paraskevi C.; Tsiodras, Sotirios

doi:10.3390/microorganisms8091383

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Professional farmers have obviously appreciated the importance of preventing the development of antibiotic resistance in their herds. This had been repeatedly underlined in many relevant campaigns in Greece, staged by various public and private organisations within their areas of responsibility [19]. One such campaign was initiated by the Hellenic Veterinary Association [20] and involved the production of leaflets for farmers and the distribution to professionals to inform them about the significance of resistant bacterial isolates for the animals (e.g., increased animal morbidity and adverse financial effects) and the potential transmission to humans.…”

Section: Predictors For Antibiotic-resistant Staphylococcal Isolatesmentioning

confidence: 99%

Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality and Risk Factors for Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Goat Herds

et al. 2021

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The objectives of this work were to study the prevalence and the patterns of antibiotic resistance of staphylococcal isolates from bulk-tank milk of goat herds across Greece, to assess possible associations of the presence of antibiotic resistance with the quality of milk in these herds and to evaluate herd-related factors potentially associated with the presence of antibiotic resistance among these staphylococcal isolates. A cross-sectional study was performed on 119 goat herds in Greece. Bulk-tank milk samples were collected for bacteriological examination; staphylococcal isolates were evaluated for resistance to 20 antibiotics. Oxacillin-resistant, resistant to at least one antibiotic, and multi-resistant staphylococcal isolates were recovered from 5.0%, 30.3%, and 16.0% of herds, respectively. Of 80 isolates, 7.5% were resistant to oxacillin, 50.0% were resistant to at least one antibiotic and 27.5% were multi-resistant. Resistance was seen more frequently among coagulase-negative staphylococci (59.3%) than among Staphylococcus aureus (23.8%). Resistance was more frequent against penicillin and ampicillin (41.3% of isolates) and fosfomycin (27.5%). No association was found with biofilm formation by staphylococci. For recovery of oxacillin-resistant isolates, the presence of working staff in the herds emerged as a significant factor; respective factors for the isolation of staphylococci resistant to at least one antibiotic were part-time farming and high (>10) number of systemic disinfections in the farm annually. The same three factors concurrently were also identified to be significant for the recovery of multi-resistant isolates.

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Section: Predictors For Antibiotic-resistant Staphylococcal Isolatesmentioning

confidence: 99%

Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality and Risk Factors for Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Goat Herds

et al. 2021

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“…The significance of the (short) length of farming experience in the recovery of resistant isolates reflects the lack of receiving information from the extensive campaigns carried out in Greece throughout the last 30 years, aiming to inform people regarding the importance of preventing development of resistance to antibiotics. Greece has one of the highest frequencies of resistance, found alike in community and hospital strains [36], and many public or private organizations have set up relevant campaigns within their areas of responsibility. One such campaign was staged by the Hellenic Veterinary Association [37], with leaflets produced for farmers to inform them about the importance of resistant bacterial isolates for the animals, as well as about the potential transmission to humans.…”

Section: Predictors For Antibiotic-resistant Staphylococcal Isolatesmentioning

confidence: 99%

Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Sheep Flocks: Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality, and Risk Factors

Lianou

Petinaki

Cripps

et al. 2021

Biology

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The objectives of this work were to study prevalence and characteristics of resistance to antibiotics of staphylococcal isolates from the bulk-tank milk of sheep flocks across Greece, to assess possible associations of the presence of antibiotic resistance with the quality of milk in these flocks and to evaluate flock-related factors potentially associated with antibiotic resistance among these isolates. A cross-sectional study was performed in 325 sheep flocks in Greece. Bulk-tank milk samples were collected for bacteriological examination; staphylococcal isolates were evaluated for resistance to 20 antibiotics. Oxacillin-resistant staphylococcal isolates, isolates resistant to any antibiotic, and multi-resistant isolates were recovered from 8.0%, 30.5%, and 12.0% of flocks, respectively. Of 232 isolates, 11.6% were resistant to oxacillin, 46.1% were resistant to at least one antibiotic, and 16.4% were multi-resistant. Resistance was seen more frequently among coagulase-negative (50.6%) than among Staphylococcus aureus (31.5%) isolates. Resistance was more frequent against penicillin and ampicillin (34.1% of isolates), clindamycin (17.7%), and fosfomycin (14.2%). An association was found between biofilm formation by staphylococci and resistance to fosfomycin. For recovery of oxacillin-resistant isolates, the lack of experience by farmers emerged as a significant factor; respective factors for the isolation of staphylococci resistant to any antibiotic or multi-resistant isolates were the early stage of the lactation period (0th–1st month) and the intensive management system applied in the flocks, respectively.

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“…The infections associated with antibiotic resistant pathogens are usually accompanied by substantial morbidity and mortality along with the massive economic burden on global healthcare ( Centers for Disease Control and Prevenation, 2019 ). Unfortunately, MDR pathogens are receiving progressive identification in community-acquired infections ( Koulenti et al, 2020 ). Along with the excessive antibiotics usage in human healthcare, antibiotics used in veterinary also owe to the emergence of antibiotic resistance ( Smet et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

et al. 2021

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Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.

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Editorial for Special Issue “Multidrug-Resistant Pathogens”

Abstract: The era of injudicious use of antibiotics in both humans and animals has led to the selection of multidrug-resistant (MDR) pathogens, which in turn has left the medical community with limited therapeutic options [...]

Cited by 7 publications

References 21 publications

Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality and Risk Factors for Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Goat Herds

Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality and Risk Factors for Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Goat Herds

Antibiotic Resistance of Staphylococci from Bulk-Tank Milk of Sheep Flocks: Prevalence, Patterns, Association with Biofilm Formation, Effects on Milk Quality, and Risk Factors

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

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