Editorial for the Special Issue on Biosensors and MEMS-Based Diagnostic Applications

Altıntaş, Zeynep

doi:10.3390/mi12030229

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Biosensors are powerful analytical devices in several areas such as medicine, food safety, wastewater treatment, and environmental analysis. − Biosensors are multiadvantage devices that besides high selectivity, sensitivity, and low cost have the potential of miniaturization for on-site monitoring . Following the IUPAC definition, a biosensor is made up of three major parts: a biological recognition element (bioreceptor, e.g.…”

Section: Introductionmentioning

confidence: 99%

Membrane-Based NEMS/MEMS Biosensors

Stapf,

Selbmann,

Joseph

et al. 2024

ACS Appl. Electron. Mater.

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Membrane-based nano/microelectromechanical system (NEMS/MEMS) biosensors offer sustainable, costeffective, ultraminiaturized and easy-to-use analytical techniques for various applications, especially in the environmental and biomedical/pharmaceutical fields. Compared to cantilever-based MEMS/NEMS biosensors, membrane-based MEMS/NEMS biosensors have higher sensitivity, especially for liquid samples, as the back of the membrane is not in contact with the analyte solution, resulting in a higher signal-to-noise ratio. This review provides deep insight into the fundamentals, membrane materials, different biosensing designs, as well as various transducers used in membrane-based MEMS/NEMS biosensors. The performance of the developed membrane-based MEMS/NEMS biosensors is critically discussed, and their trends and challenges are highlighted. Among the reported biosensors, capacitive-based surface stress biosensors and capacitive micromachined ultrasonic transducer (CMUT) biosensors are emerging as sophisticated and sensitive platforms for biosensing with the ability to detect multiple targets simultaneously. Nevertheless, challenges remain in biosensor design, parameter optimization, and selection of appropriate membrane materials. Further research is imperative to improve the capabilities of these biosensors, particularly in advancing array technologies for the simultaneous detection of multiple analytes.

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