The unprecedented outbreaks of monkeypox viruses in non-endemic regions have created grave concern for global health. The World Health Organization has declared a public health emergency of international concern and stated the seriousness of monkeypox viruses. The gravity of this zoonotic disease cannot be underestimated, owing to the fact that this viral infection can cause pathetic situations if ignored. Keeping these lacunas, the scientific communities have expressed their interest towards the study of monkeypox viruses. Hence the present review discusses the etiological features, historical events, and vaccination along with management strategies to combat and counter the sudden outbreak. The review also highlights the current Indian scenario of the monkeypox virus; with scanty reports available, the present contributes towards the growing scientific knowledge to prevent a future threats to mankind.