Editorial: Insights in neuroinflammation and neuropathy

Chiu, Ching-Chi; Lee, Hsueh-Te; Kuo, Yao‐Haur

doi:10.3389/fnagi.2022.1060271

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…These symptoms can range from fatigue, cognitive issues, memory loss, neuropathy, joint pain, musculoskeletal pain, to sleep issues, nausea, depression, and others ( 6 , 7 ). Persistent neuroinflammation may be a likely source of such symptoms as many studies have shown a link between neuroinflammatory processes and cognitive defects, fatigue, neuropathy, autoimmune diseases, and others ( 8 – 10 ). In support of this, PET scans of PTLDS patients show likely glial activation in the brain, several months post-treatment ( 11 ), indicating on-going neuroinflammation.…”

Section: Introductionmentioning

confidence: 99%

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo

Parthasarathy

2024

Front. Immunol.

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In previous studies, we showed that fibroblast growth factor receptors (FGFRs) contribute to inflammatory mediator output from primary rhesus microglia in response to live Borrelia burgdorferi. We also demonstrated that non-viable B. burgdorferi can be as pathogenic as live bacteria, if not more so, in both CNS and PNS tissues. In this study we assessed the effect of live and non-viable B. burgdorferi in inducing FGFR expression from rhesus frontal cortex (FC) and dorsal root ganglion (DRG) tissue explants as well as their neuronal/astrocyte localization. Specific FGFR inhibitors were also tested for their ability to attenuate inflammatory output and apoptosis in response to either live or non-viable organisms. Results show that in the FC, FGFR2 was the most abundantly expressed receptor followed by FGFR3 and FGFR1. Non-viable B. burgdorferi significantly upregulated FGFR3 more often than live bacteria, while the latter had a similar effect on FGFR1, although both treatments did affect the expressions of both receptors. FGFR2 was the least modulated in the FC tissues by the two treatments. FGFR1 expression was more prevalent in astrocytes while FGFR2 and FGFR3 showed higher expression in neurons. In the DRG, all three receptor expressions were also seen, but could not be distinguished from medium controls by immunofluorescence. Inhibition of FGFR1 by PD166866 downregulated both inflammation and apoptosis in both FC and DRG in response to either treatment in all the tissues tested. Inhibition of FGFR1-3 by AZD4547 similarly downregulated both inflammation and apoptosis in both FC and DRG in response to live bacteria, while with sonicated remnants, this effect was seen in one of the two FC tissues and 2 of 3 DRG tissues tested. CCL2 and IL-6 were the most downregulated mediators in the FC, while in the DRG it was CXCL8 and IL-6 in response to FGFR inhibition. Downregulation of at least two of these three mediators was observed to downregulate apoptosis levels in general. We show here that FGFR inhibition can be an effective anti-inflammatory treatment in antibiotic refractive neurological Lyme. Alternatively, two biologics may be needed to effectively curb neuroinflammation and pathology in the CNS and PNS.

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Section: Introductionmentioning

confidence: 99%

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo

Parthasarathy

2024

Front. Immunol.

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“…The molecular mechanism of its occurrence and progression is complex and remains to be explored. Important known mechanisms include mitochondrial DNA damage, ROS damage, noise, neuroinflammation, pyroptosis, and so on (7)(8)(9)(10). In addition to coding genes, the effects of miRNAs on ARHL have received increasing attention in recent years.…”

Section: Introductionmentioning

confidence: 99%

Key genes and potential drugs in age-related hearing loss: transcriptome analysis of cochlear hair cells in old mice

Xiaoran Yang,

Guihua Wang,

Weimin Liu

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Materials and Methods Selection of presbycusis-related datasetsWe selected the GEO datasets in studies of cochlear hair cells using the term "presbycusis". The criteria were that the mice were divided into at least two groups: an old group and a young group, where the old group was at least 12 months of age, and the young group was less than or equal to 9 months. Overall, five datasets were collected: GSE153882, GSE121856, GSE98070, GSE45026, and GSE98071. The former three datasets provide the expression profiles of mRNAs, and the last two datasets provide that of miRNAs. Differentially expressed genesAll the datasets were analyzed with the DESeq2 R package to acquire the differentially expressed genes (DEGs). The fold change (FC) and P-value were obtained for each

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Editorial: Insights in neuroinflammation and neuropathy

Cited by 2 publications

References 9 publications

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo

Fibroblast growth factor receptor inhibitors mitigate the neuropathogenicity of Borrelia burgdorferi or its remnants ex vivo

Key genes and potential drugs in age-related hearing loss: transcriptome analysis of cochlear hair cells in old mice

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