Editorial: Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer

Naor, David

doi:10.3389/fimmu.2016.00039

Cited by 66 publications

(39 citation statements)

References 12 publications

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“…However, clues are provided by previous reports. For example, extracellular RHAMM binds to HA fragments in the size range that has recently been reported to suppress adipogenesis[74, 75] and associates with transmembrane receptors such as CD44 and PDGFR[73, 76, 77] to regulate activation of ERK1,2 signaling pathways controlling mesenchymal differentiation [73, 77]. Furthermore, intracellular RHAMM protein isoforms complex with, sustain activity and regulate subcellular targeting of the MEK1/ERK1,2 complexes that affect adipogenesis [38].…”

Section: Discussionmentioning

confidence: 99%

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

et al. 2017

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Hyaluronan, CD44 and the Receptor for Hyaluronan-Mediated Motility (RHAMM, gene name HMMR) regulate stem cell differentiation including mesenchymal progenitor differentiation. Here, we show that CD44 expression is required for subcutaneous adipogenesis, whereas RHAMM expression suppresses this process. We designed RHAMM function blocking peptides to promote subcutaneous adipogenesis as a clinical and tissue engineering tool. Adipogenic RHAMM peptides were identified by screening for their ability to promote adipogenesis in culture assays using rat bone marrow mesenchymal stem cells, mouse pre-adipocyte cell lines and primary human subcutaneous pre-adipocytes. Oil red O uptake into fat droplets and adiponectin production were used as biomarkers of adipogenesis. Positive peptides were formulated in either collagen I or hyaluronan (Orthovisc) gels then assessed for their adipogenic potential in vivo following injection into dorsal rat skin and mammary fat pads. Fat content was quantified and characterized using micro CT imaging, morphometry, histology, RT-PCR and ELISA analyses of adipogenic gene expression. Injection of screened peptides increased dorsal back subcutaneous fat pad area (208.3 ± 10.4 mm2 versus control 84.11 ± 4.2 mm2; p < 0.05) and mammary fat pad size (45 ± 11 mg above control background, p=0.002) in female rats. This effect lasted >5 weeks as detected by micro CT imaging and perilipin 1 mRNA expression. RHAMM expression suppresses while blocking peptides promote expression of PPARγ, C/EBP and their target genes. Blocking RHAMM function by peptide injection or topical application is a novel and minimally invasive method for potentially promoting subcutaneous adipogenesis in lipodystrophic diseases and a complementary tool to subcutaneous fat augmentation techniques.

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Section: Discussionmentioning

confidence: 99%

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

et al. 2017

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“…Hyaluronic acid (HA), as a natural polysaccharide produced by fibroblasts in the wound repair stages of proliferation, can mediate cellular signaling, promote cell migration, and induce morphogenesis and matrix organization, which enhances the repair process of soft tissue wound . Besides, HA has good biocompatibility, biodegradability, moisture retention, and gelation property, which favors the design of injectable hydrogel dressing.…”

Section: Introductionmentioning

confidence: 99%

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Liang

Zhao

et al. 2019

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Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full‐thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid‐graft‐dopamine and reduced graphene oxide (rGO) using a H2O2/HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self‐healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full‐thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full‐thickness skin repair.

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“…HA immunostaining induces proliferation signals through its main receptor, CD44, then the interaction of HA with CD44 can increase invasion, motility and proliferation of tumor cells. The HA-CD44 complex triggers the receptor tyrosine kinase signalling process, other signal receptors (TGFßR1), and non-receptor kinase, and through the MAP kinase pathway and induces proliferation via the CDK-2 pathway by suppressing the inhibitor, p27 (kip1) and hyperphosphorylation of Rb protein and CD44 differently expresses the BMI1 gene (Gadhoum et al 2004, Loderbough & Schroeder 2011, Naor 2016, Patel et al 2017.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of KI-67, Apoptosis, and Hyaluronic Acid in Grading Retinoblastoma

Soebagjo

Nurwasis

Bintoro

et al. 2019

FMI

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Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular weight has the property of angiogenesis, inflammation, and suppresses apoptosis. This study occupied the samples of 35 paraffin block from poorly and well differentiated retinoblastoma tissue and 8 normal retinal block which have been collected for 4 years from 2010-2013 Afterwards, the paraffin blocks were immunohistochemically examined for HA staining, expression of cell proliferation , and cell apoptosis to determine intratumoral aggressiveness of retinoblastoma. HA on poorly differentiated retinoblastoma stain with a high immunostaining of 76.2%, while well differentiated retinoblastoma on the highest HA staining was revealed to be at moderate level of 64.3%, and not appear in normal retina. In poorly differentiated retinoblastoma, the location of most HA stain is in the cell cytoplasm (87.5%). In the well differentiated retinoblastoma, the HA immunostaning mainly occurred in the cell membrane (73.7%). Histopathological retinoblastoma grading showed a significant correlation (p <0.01) towards several variables of HA immunostaining, Ki-67, and cell apoptosis. In addition, the histopathological retinoblastoma grading also revealed a significant correlation (p <0.01) towards the location of HA staining (cell membrane and cytoplasm). Both stainings are also play role in retinoblastoma differentiation. The malignancy of retinoblastoma can be proven by the increased HA staining at cytoplasm in poorly differentiated and associated with increased of cell proliferation along with decreased apoptosis. ABSTRAKAsam hialuronat (HA) merupakan senyawa glikosaminoglikan dengan polimer rantai lurus yang berfungsi mengisi matriks ekstraseluler. HA dengan berat molekul besar memiliki sifat fisikokimia, biologis, dan fisiologis normal sedangkan berat molekul rendah berperan dalam proses angiogenesis, inflamasi, dan supresi apoptosis. Penelitian ini menggunakan 35 sampel blok parafin jaringan poorly dan well differentiated retinoblastoma serta 8 blok retina normal yang dikoleksi selama 4 tahun dari tahun 2010-2013 di RSUD Dr. Soetomo, Surabaya, Indonesia. Setelah itu, blok parafin diuji imunohistokimia dengan pewarnaan HA, ekspresi proliferasi sel (Ki-67), dan apoptosis sel untuk melihat agresivitas retinoblastoma intratumoral. Pewarnaan HA pada poorly differentiated retinoblastoma menunjukkan pewarnaan yang tinggi sebesar 76.2%, sedangkan pada well differentiated retinoblastoma menunjukkan pewarnaan yang tinggi pada tingkat sedang sebesar 64.3%, dan tidak muncul pada retina normal. Pada poorly differentiated retinoblastoma, rata-rata pewarnaan HA muncul di sel sitoplasma (87.5%). Pada well differentiated retinoblastoma, pewarnaan HA rata-rata muncul di area membran sel (73.7%). Grading histopatologis retinoblastoma menunjukkan korelasi signifikan terhadap beberapa variabel yaitu pew...

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Editorial: Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer

Cited by 66 publications

References 12 publications

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Evaluation of KI-67, Apoptosis, and Hyaluronic Acid in Grading Retinoblastoma

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