Editorial: NK/T-Cell Lymphoma: Biology, Prognostics, Prediction, and Treatment

Cheikh, Jean El; Terro, Khodr; Sharrouf, Layal; Mishra, Anjali; Lima, Marcos de

doi:10.3389/fonc.2022.942299

Cited by 1 publication

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“…Extranodal nasal NK/T-cell lymphoma (extranodal natural killer (NK)/T-cell lymphoma, nasal type, ENKTCL-NT or NKTCL), a relatively rare subtype of non-Hodgkin lymphoma, is a class of neoplasms with special morphology, immunophenotype and biological behavior, which is highly aggressive, with rapid disease progression and poor prognosis (1)(2)(3). The disease often invades the upper respiratory tract such as the nasal cavity, paranasal sinuses, etc, causing severe damage to the soft tissues and bone.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of IL-22, IL-23, and IL-17 for NK/T cell lymphoma

Yan¹,

Liao²,

Chen³

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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NK/T cell lymphoma (NKTCL) is a common blood cancer, and early diagnosis of this disease is crucial. This study is aimed to investigate the roles of IL-17, IL-22 as well as IL-23 for the diagnosis of NKTCL. Sixty-five patients with NKTCL were included and the blood samples were collected, and sixty healthy objectives served as the controls. Serums of the patients and controls were collected. The expression levels of IL-17, IL-22, and IL-23 were examined using enzyme-linked immunosorbent (ELISA) assay. The receiver operator characteristic (ROC) curve was drawn for determining the potential diagnostic value of these cytokines. The serum levels of IL-17 (156.0 ± 67.75 pg/mL), IL-22 (39.98 ± 23.88 pg/mL), and IL-23 (43.05 ± 25.69 pg/mL) were all markedly increased in NKTCL patients (P<0.001); ROC analysis showed the serum level of IL-17, IL-22, and IL-23 could serve as the potential diagnostic biomarker for NKTCL with high sensitivity and specificity. The AUC of IL-17 was 0.9487 (95% confidence interval (CI), 0.9052 to 0.9922). Area under the curve (AUC) of IL-22 was 0.7321 (95% CI, 0.6449 to 0.8192). The AUC of IL-23 was 0.7885 (95% CI, 0.7070 to 0.8699). Our data indicated that IL-17, IL-22, and IL-23 were all increased in NKTCL and may function as potential diagnostic biomarkers for NKTCL.

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Section: Introductionmentioning

confidence: 99%