Editorial: Precision medicine: recent advances, current challenges and future perspectives

Awwad, Oriana; Ahram, Mamoun; Coperchini, Francesca; Jalil, Mariam Abdel

doi:10.3389/fphar.2024.1439276

Cited by 2 publications

References 6 publications

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Precision Medicine in View of Genomic Biomarker Discovery

Kohli,

Verma,

Agarwal

et al. 2024

Advances in Medical Technologies and Clinical Practice

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Precision Medicine encompasses decision making about prevention, diagnosis, and treatment of a particular disease in a patient tailored based on the information derived from a patient's genetic profile, environment, and lifestyle. It is patient-specific based on their specific clinical and biological characteristics with minimum side effects. With advancements in DNA sequencing technology, this concept gained attention among scientists. The projects like Human Genome Project and International HapMap Project provided deep insight into human genomics and information about specific disease-associated gene variants. Moreover, pharmacogenetics and pharmacogenomics have helped in understanding molecular basis of diseases and corresponding therapeutic strategy designed for individuals for a particular drug and the effect of multiple variations in genome on drug treatment, helping biomarker identification, influencing pathogen and drug effects on body, establishing the need for genomic biomarkers discovery for designing patient-specific treatment modalities for a specific disease.

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Precision Medicine in View of Genomic Biomarker Discovery

Kohli,

Verma,

Agarwal

et al. 2024

Advances in Medical Technologies and Clinical Practice

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Medicina personalizada y farmacogenómica en el tratamiento de enfermedades cardiovasculares

Villa-Feijoó

2024

Horizon Nexus Journal

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The article discusses the application of personalized medicine and pharmacogenomics in the treatment of cardiovascular disease, highlighting their ability to improve drug efficacy and reduce adverse effects. Through a literature review, the study examines how genetic variants in genes such as CYP2C19 and SLCO1B1 influence the response to common drugs such as statins and clopidogrel. The results indicate that tailoring doses according to a patient's genetic profile not only improves clinical outcomes, but also reduces the incidence of serious side effects, such as myopathies and thrombosis. Despite these benefits, clinical implementation faces significant barriers, such as the high costs of genetic testing and the lack of access to advanced technology in some regions. The study concludes that, although pharmacogenomics has the potential to transform the treatment of cardiovascular diseases, its widespread adoption will depend on overcoming these barriers.

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Editorial: Precision medicine: recent advances, current challenges and future perspectives

Cited by 2 publications

References 6 publications

Precision Medicine in View of Genomic Biomarker Discovery

Precision Medicine in View of Genomic Biomarker Discovery

Medicina personalizada y farmacogenómica en el tratamiento de enfermedades cardiovasculares

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