Editorial: <scp>STAT</scp>‐4 polymorphism ‐ a tool to personalise clinical practice in chronic <scp>HBV</scp> infection. Authors’ reply

Sharkawy, Rasha El; George, Jacob; Eslam, Mohammed

doi:10.1111/apt.14940

Cited by 1 publication

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“…STAT4 expression has also been associated with numerous malignancies, such as ovarian and lung cancer [ 17 , 18 ]. It has been theorized that reduced STAT4 expression, induced by the SNP, could potentially weaken the anti-tumor response by affecting STAT4 modulation of interleukin 12 in NK cells [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans

Ayoub,

Anugwom,

Prieto

et al. 2023

Cancers

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The STAT4 rs7574865 genetic variant has been associated with an increased risk of developing HCC in Asian populations. However, this association has not been studied in Latin America and is poorly assessed in European populations. This case-control study investigated the association between STAT4 rs7574865 and HCC risk in these populations. We evaluated DNA samples from seven medical institutions across six Latin American countries and one Dutch institution in 1060 individuals (344 HCC and 716 controls). STAT4 rs7574865 SNP was genotyped using TaqMan-genotyping assay and analyzed using logistic regression. We found no significant association between the homozygous risk allele (G) of STAT4 and HCC development in either population, with odds ratios (OR) for GG versus TT of 0.85 (CI: 0.48–1.52, p = 0.58) and 0.81 (CI: 0.34–1.93, p = 0.67) for Latin Americans and Europeans respectively. No correlation was found between the risk allele and HCC based on underlying liver disease. However, we found that Latin Americans of European ancestry were more likely to carry the risk allele. Our results suggest that the STAT4 SNP rs7574865 does not influence the risk of developing HCC in Latin American or European populations, highlighting the importance of evaluating genetic risk factors in various ethnic groups and understanding the possible influence of ancestry on the genetic basis of disease.

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Section: Introductionmentioning

confidence: 99%

Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans

Ayoub,

Anugwom,

Prieto

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

Editorial: STAT‐4 polymorphism ‐ a tool to personalise clinical practice in chronic HBV infection. Authors’ reply

Abstract: Linked ContentThis article is linked to El Sharkawy et al and Bonacci and Lens papers. To view these articles visit https://doi.org/10.1111/apt.14866 and https://doi.org/10.1111/apt.14924.

Cited by 1 publication

References 10 publications

Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans

Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans

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