Editorial: Spotlight on the Relationship Between Sepsis and Infection: From Mechanisms to Therapy

Lights and Shadows of Sepsis Management: Challenges and Future Perspectives

“…The rapid spread of MDR microorganisms, due mainly to the disproportionate use of antibiotics, highlights an urgent issue about the management and treatment of sepsis, especially in countries with scarce economic resources [10]. Ideal techniques should include a number of features, such as rapid microbiological results, low invasiveness, high sensitivities, and high specificities, but also the ability to differentiate between host-and pathogen-mediated inflammatory responses to influence clinical management to obtain a targeted therapeutic approach as soon as possible [11][12][13]. Due to the difficulty in understanding the mechanisms of sepsis and limitations in current diagnostic procedures, there is great interest in identifying promising biomarkers that can not only predict mortality rates but also be used as indices of the early detection of inflammation status.…”