Editorial: TGF-β in Human Disease: Friend or Foe?

Zheng, Guoping; Harris, David C.H.

doi:10.3389/fcell.2021.739172

Cited by 3 publications

(2 citation statements)

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“…The latter contributes to the angiogenesis and tissue regeneration. 12 Antioxidants are agents that could oppose adverse effects of oxidation from intracellular compounds. 13 Based on their mechanism of action, antioxidants are divided into three groups, including primary, secondary and tertiary ones.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant therapy against TGF‐β/SMAD pathway involved in organ fibrosis

Ghafouri‐Fard,

Askari,

Shoorei

et al. 2023

J Cellular Molecular Medi

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Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in different organs. In recent years, it has been revealed that different cytokines and chemokines, especially Transforming growth factor beta (TGF‐β) is involved in the pathogenesis of fibrosis. It has been shown that TGF‐β is upregulated in fibrotic tissues, and contributes to fibrosis by mediating pathways that are related to matrix preservation and fibroblasts differentiation. There is no doubt that antioxidants protect against different inflammatory conditions by reversing the effects of nitrogen, oxygen and sulfur‐based reactive elements. Oxidative stress has a direct impact on chronic inflammation, and as results, prolonged inflammation ultimately results in fibrosis. Different types of antioxidants, in the forms of vitamins, natural compounds or synthetic ones, have been proven to be beneficial in the protection against fibrotic conditions both in vitro and in vivo. In this study, we reviewed the role of different compounds with antioxidant activity in induction or inhibition of TGF‐β/SMAD signalling pathway, with regard to different fibrotic conditions such as gastro‐intestinal fibrosis, cardiac fibrosis, pulmonary fibrosis, skin fibrosis, renal fibrosis and also some rare cases of fibrosis, both in animal models and cell lines.

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Section: Introductionmentioning

confidence: 99%

“…Another aspect of TGF‐β functions which is associated with human disorders is remodelling and repair process. The latter contributes to the angiogenesis and tissue regeneration 12 …”

Section: Introductionmentioning

confidence: 99%