Editorial to the Special Issue: “Dedicated to the 55th Anniversary of G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences”

Dmitrenok, Pavel S.

doi:10.3390/molecules26164971

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Thanks to the research projects of PIBOC, every year, the arsenal of marine natural compounds is replenished with 50-100 new representatives (alkaloids, polar steroids, glycosides, cerebrosides, terpenoids, quinonoid metabolites, and peptides), many of which exhibiting antitumor, immunomodulatory, antibacterial, antioxidant, anti-inflammatory and neuroprotective properties. Further, the PIBOC Collection of marine microorganisms (official acronym KMM) includes over 4000 axenic strains of marine bacteria and fungi [20].…”

Section: Introduction: the Russian Pacificmentioning

confidence: 99%

Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases

Silachev

Katanaev

2022

Marine Drugs

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Neurodegenerative diseases are growing to become one of humanity’s biggest health problems, given the number of individuals affected by them. They cause enough mortalities and severe economic impact to rival cancers and infections. With the current diversity of pathophysiological mechanisms involved in neurodegenerative diseases, on the one hand, and scarcity of efficient prevention and treatment strategies, on the other, all possible sources for novel drug discovery must be employed. Marine pharmacology represents a relatively uncharted territory to seek promising compounds, despite the enormous chemodiversity it offers. The current work discusses one vast marine region—the Northwestern or Russian Pacific—as the treasure chest for marine-based drug discovery targeting neurodegenerative diseases. We overview the natural products of neurological properties already discovered from its waters and survey the existing molecular and cellular targets for pharmacological modulation of the disease. We further provide a general assessment of the drug discovery potential of the Russian Pacific in case of its systematic development to tackle neurodegenerative diseases.

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Section: Introduction: the Russian Pacificmentioning

confidence: 99%