Editorial: topiramate for cyclic vomiting syndrome—for refractory patients only? Authors' reply

Abstract

We thank Drs Rangan and Lembo for their insightful comments on our study on the effectiveness of topiramate as a prophylactic agent in cyclic vomiting syndrome (CVS). 1,2 Recent guidelines conditionally recommend that adults with moderate-to-severe CVS receive topiramate as an alternative prophylactic medication. 3 The guide-