Educational Case: Hypersensitivity Vasculitis

Abstract

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040 . 1

Drug‐induced vasculitis: Thiazide or the COVID‐19 vaccine, which one is guilty? A case report and literature review

“…Pathologic findings have a substantial role in eliminating infectious causes or malignancies. They can also determine the presence of immune complexes in the small vessels 9 . Finally, we were curious whether the administration of COVID‐19 vaccines could result in vasculitis.…”

“…They can also determine the presence of immune complexes in the small vessels. 9 Finally, we were curious whether the administration of COVID‐19 vaccines could result in vasculitis. Although there have recently been some reports about the use of mRNA based COVID‐19 vaccines as a cause of leukocytoclastic vasculitis, 10 , 11 , 12 , 13 , 14 the role of inactivated whole virus vaccines such as Sinopharm, Sinovac (CoronaVac), and COVAXIN (Bharat Biotech) should not be overlooked 15 , 16 , 17 .…”