Background: Maintaining patients’ safety is a basic professional role of radiographers. Therefore, the present study aimed to evaluate the technical, protective, and technological operation of interventional radiologists. Objectives: The current study aimed to determine the protective and technical performance of radiographers and their knowledge and expertise. Methods: In this descriptive-analytical study, 60 radiographers working in radiology wards of hospitals affiliated to the Zahedan University are included. A checklist whose reliability and validity were previously established was used to collect data. For the radiography staff, 17 technical and 12 protective items were checked and recorded during three work shifts. Data were analyzed by SPSS. Results: The performance score of 27 males (45%) and 33 females (65%) was assessed. Seven factors of radiology staff, including gender, employment status, age, work experience, number of shifts, Work Shift, and Education, were evaluated, and that number of shifts was statistically significant. Conclusions: The radiographers’ awareness of technical and protective principles was at a medium level. Increasing attention to the quality of academic training and continuous education is necessary.