EEG response to hyperventilation in patients with CNS disorder

Khachidze, Irma; Gugushvili, M.; Inasaridze, K; Advadze, M

doi:10.15761/gimci.1000188

Cited by 1 publication

(7 citation statements)

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“…The sample used for this study has been described elsewhere ( 23 , 24 , 30 ). Briefly, in our previous studies, 2,186 patients were recruited according to the EEG responses to hyperventilation.…”

Section: Methodsmentioning

confidence: 99%

“…PERH-II—high-amplitude, generalized, monomorphic or polymorphic, slow, synchronous waves with paroxysmal discharges without epileptic elements. PERH-III was shown epileptic activity, both with generalized paroxysmal discharges and individual graph elements of epilepsy ( 23 , 24 , 30 ). The diagnosis was made according to neurological examination and clinical assessment by medical doctors and collected from clinical history.…”

Section: Methodsmentioning

confidence: 99%

“…The changes in the EEG characteristics for the whole group were assessed by the Wilcoxon Signed-Ranks test (33). It was reported in our previous studies (23,24,30). Data analysis was done using the software package of statistical data processing SPSS 20.0 to check and evaluate the result.…”

Section: Data Management and Statistical Analysismentioning

confidence: 99%

“…However, it is not evident how pathological EEG responses to hyperventilation (PERH) may reveal dysfunction of the CNS in humans. Although it is well-established that brain processes during development contribute to the manifestation and/or efficacy of treatments of brain disorders, data on the response to HPT in people with various functional disorders of the CNS is limited ( 9 , 24 , 25 ). Additionally, only a few studies described the role of age and biological sex (female, male) ( 26 , 27 ) in patients with CNS dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

“…This type of research and interpretation of the results will be essential and informative in evaluating and investigating neurobiological mechanisms of neurodevelopmental and neurodegenerative disorders in men and women with different age ranges. In our previous studies, we described pathological EEG responses to hyperventilation in individuals with various CNS dysfunctions ( 23 , 24 , 30 ). Three types of pathological responses: I, II, and III were documented.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

EEG Characteristics to Hyperventilation by Age and Sex in Patients With Various Neurological Disorders

Khachidze¹,

Gugushvili²,

Advadze

2021

Front. Neurol.

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Introduction: Hyperventilation provocation test(s) (HPT) concomitant to electroencephalography (EEG) may detect hidden disorders of the nervous system (CNS). There are various types of abnormal EEG in responses to HPT that provoke different interpretations. However, it is not evident how the onset time of pathological EEG responses to hyperventilation (PERH) reveals dysfunction of the CNS in humans. It is also not clear if age and biological sex affect EEG characteristics in response to HPT. Our previous studies have revealed three types of PERH (disorganization of basic rhythm, paroxysmal discharges, epileptiform activity) concerning the manifestation time of first, second, and third minutes. The current work aims to classify the PERH with regards to age (3–6, 7–12, 13–18, 19–30, 31–50, 50 > year) and the biological sex of the patients.Methods: This study examined the EEG of 985 outpatients with various functional disorders of the CNS. The patients were assigned to one of three experimental groups based on the time occurrence of PERH in response to the HPT.Results: The disorganized basic EEG rhythm in the first, second, third minute of HPT was observed across all age and sex groups. All three types of PERH in the first minute were comparable for both sexes. However, some discrepancies between females compared to males were observed in the second and third minutes. All three types of PERH in the first and the second minutes were found only in women. The second type of PERH has revealed at the second minute of PHT in 13–18-year-old five girls.Conclusion: The three main types of PERH were detected at the first minute in all age groups and sex in patients with various CNS dysfunctions. It is diagnostically informative should be used as a marker during the monitoring of treatment. The specific activity of the brain's response to HPT depends on time, age, sex. The data indicate that taking into account sex differences and age during HPT leads to better results. The sensitivity and severity of the NS reaction toward hypocapnia, stress, and emotion increase in women. Therefore, in such cases should not be recommended to expand functional loads.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%