Efecto regional, de la edad y el sexo en la espectroscopia por resonancia magnética cerebral

Santos, J.M. García; Fuentes, Luis J.; Vidal, Juan Bautista; Antequera, Martirio; Río, Silvia Torres del; Antúnez, Carmen; Ortega, G.

doi:10.1016/j.rx.2010.04.005

Cited by 6 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was only observed that in the frontal lobe of the left hemisphere ml/Σ concentrations were considerably higher in the male subjects and NAA concentrations were significantly higher in the female subjects. Similar results were obtained worldwide by other research teams; in most 1 HMRS examinations of the brain, sex differences in the concentrations of NAA, mI, Cho, Cr, Lip, and Lac were negligible or completely invisible [ 2 , 8 , 18 , 20 , 21 ].…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

et al. 2018

View full text Add to dashboard Cite

PurposeThe aim of this 1HMRS study was to define sex-related differences in metabolic spectrum between healthy children. Forty-nine girls and boys aged 6-15 years were examined.Material and methodsVolume of interest was located in seven brain regions: frontal lobes, basal ganglia, hippocampi, and cerebellum.ResultsStatistical analysis of the results showed significantly higher (p < 0.05) myo-inositol concentrations relative to the total concentrations in the boys than the girls, as well as higher absolute N-acetyl aspartate concentrations in the left frontal lobes in girls. No other significant differences were shown, except for trends in differences.ConclusionsIn clinical practice the diagnostic process first of all focuses on assessing concentrations of metabolites to relative cerebellum concentration. Thus, the findings of the present study allow the conclusion that when analysing the results of 1HMRS studies in children it is not necessary to take into account the child’s gender.

show abstract

Section: Discussionsupporting

confidence: 88%

“…Such tendencies indicating differences in metabolite concentrations were found in the case of the Cho/Cr ratio in the cerebellum and mI in the left frontal lobe as well as the right hippocampus. In the left frontal lobe NAA/Cr and Cho/Cr ratios are higher in women [ 8 ]. Komoroski et al .…”

Section: Discussionmentioning

confidence: 99%

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Frontal lobes are largely responsible for reasoning and memory processes. In this study, NAA/Cr and mI/Cr ratios were differed significantly between the frontal lobe and the hippocampus which was in line with the results obtained by Santos [ 11 ] in a group of young patients (age <30 years). Santos demonstrated significant differences in NAA/Cr, Cho/Cr, and mI/Cr ratios.…”

Section: Discussionsupporting

confidence: 93%

Regional Differences in the Concentrations of Metabolites in the Brain of Healthy Children: A Proton Magnetic Resonance Spectroscopy (1HMRS) Study

et al. 2016

View full text Add to dashboard Cite

SummaryBackgroundThe aim of this 1HMRS study was to identify any potential regional differences in the metabolic spectrum in the brains of healthy children.Material/MethodsForty-nine healthy children aged 6–15 years (mean 11.6 years) were examined, including 21 girls and 28 boys. A 1.5T MR system (xi Signa HD 1.5T General Electric) was used in patient examinations. The VOI (Volume of Interest) was defined in 7 locations: the frontal lobe in the right and left hemispheres, the basal ganglia in the right and left hemispheres, hippocampus in the right and left hemispheres and cerebellum. SAGE 7.0 software was used for the analysis of data obtained from the 1HMRS study. Differences in the concentrations of metabolites in various regions of the brain in children were verified using the t-test for independent samples.ResultsThere were significant differences in concentration levels between various brain regions for all the examined metabolites. NAA was the metabolite characterized by the greatest regional variation with significant differences being observed between all locations. Only in the case of Lip/Cr and the ratio of the Lip concentration to the sum of the concentrations of all the metabolites no significant differences could be observed.ConcluisonsThe results of the study show that a child’s brain is inhomogeneous. The results underline the need of the regional differences in the concentrations of metabolites being taken into account when comparing the results of 1HMRS studies in children.

show abstract

From fetus to older age: A review of brain metabolic changes across the lifespan

Cichocka

Bereś

2018

Ageing Research Reviews

View full text Add to dashboard Cite

Efecto regional, de la edad y el sexo en la espectroscopia por resonancia magnética cerebral

Cited by 6 publications

References 36 publications

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

Sex differences in brain metabolite concentrations in healthy children – proton magnetic resonance spectroscopy study (<sup>1 </sup>HMRS)

Regional Differences in the Concentrations of Metabolites in the Brain of Healthy Children: A Proton Magnetic Resonance Spectroscopy (1HMRS) Study

From fetus to older age: A review of brain metabolic changes across the lifespan

Contact Info

Product

Resources

About