Efectos del sobrepeso y la obesidad en las funciones cognitivas de niños y adolescentes

Nicolovius, Margarita Martí

doi:10.33588/rn.7503.2022173

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…With the increased prevalence of obesity and the earlier onset of obesity in the population, there may be a significant rise in the incidence and prevalence of Alzheimer’s disease among younger individuals [ 15 ]. Childhood obesity, which is highly prevalent, has been linked to various health issues, including cognitive impairment during childhood [ 16 , 17 ]. Longitudinal studies examining the association between childhood obesity and cognitive function in midlife have revealed that childhood obesity has a detrimental effect on cognition later in life [ 18 ].…”

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confidence: 99%

Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study

Qing,

Qian

2024

Arch Public Health

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Background Midlife obesity is a modifiable risk factor for Alzheimer’s disease. However, the association between childhood obesity and Alzheimer’s disease remains largely unknown. Therefore, we conducted a mendelian randomization analysis (MR) to assess the causal link between childhood obesity and Alzheimer’s disease. Methods Using summary statistics from publicly available genome-wide association studies (GWAS) database, we explored the genetic link between childhood obesity and Alzheimer’s disease through a two-sample MR. The primary analysis employed the inverse-variance weighted (IVW) method. To complement our findings, we also employed MR-Egger, weighted median, simple model, and weighted model methods for MR estimates. Furthermore, we conducted Cochrane’s Q-statistic test, Egger intercept test, and a leave-one-out sensitivity test to ensure the robustness and reliability of our results. Results The IVW analysis yielded non-significant results, indicating no significant genetic association between childhood obesity and Alzheimer’s disease (OR = 0.958, 95% CI = 0.910–1.008, p = 0.095). Consistent with this, the results from MR-Egger, the weighted median, simple model, and weighted model approaches all supported these findings. Furthermore, we did not detect any signs of heterogeneity or pleiotropy, and our leave-one-out analysis confirmed that no single nucleotide polymorphisms had a substantial impact on the reliability of our results. Conclusions The evidence from our MR analyses suggests that there is no causal effect of childhood obesity on the risk of Alzheimer’s disease.

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Section: Introductionmentioning

confidence: 99%

Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study

Qing,

Qian

2024

Arch Public Health

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Association of anthropometric parameters with intelligence quotient in early school-aged children: a cross-sectional study in Iran

Mahjubi,

Effatpanah,

Parsaei

et al. 2024

BMC Pediatr

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Background While the link between body growth indices in the first three years of life and neurodevelopment is well established, the relationship between these indicators and intelligence levels in later stages is not well understood. This study aimed to investigate the association between various anthropometric indices and Intelligence Quotient in early school-aged children. Methods This cross-sectional study recruited healthy students aged 7 to 8 years from four primary schools in Tehran, Iran. Measurements included body weight, height, body mass index, arm circumference, waist circumference, and hip circumference. Intelligence Quotient was assessed using the Raven's Standard Progressive Matrices Test, with scores standardized by age according to the Raven's manual. Separate univariate linear regression analyses evaluated the association between each anthropometric index and children’s Intelligence Quotient scores. Multivariate linear regression analyses were then performed to adjust for potential confounding factors, including the child's sex, age, and parental education levels. Results A cohort of 160 children (80 females), with a mean age of 7.5 ± 0.6 years, was included in the study. The participants exhibited the following mean anthropometric values: weight 27.7 ± 6.5 kg, height 1.2 ± 0.1 m, body mass index 17.9 ± 3.4 kg/m 2 , arm circumference 20.7 ± 2.8 cm, waist circumference 56.4 ± 6.4 cm, and hip circumference 68.1 ± 6.6 cm. Their mean Intelligence Quotient score was 106 ± 16.6. In the univariate analysis, children's weight was not significantly associated with Intelligence Quotient score ( P -value = 0.153, β = 0.288 [-0.108, 0.684]), while height was negatively associated ( P -value = 0.048, β = -31.685 [-63.142, -0.228]) and body mass index showed a positive association ( P -value = 0.001, β = 1.265 [0.524, 2.006]). Abdominal circumference was not significantly associated with Intelligence Quotient ( P -value = 0.913, β = 0.051 [-0.870, 0.972]), but both waist circumference ( P -value = 0.007, β = 0.542 [0.147, 0.937]) and hip circumference ( P -value = 0.013, β = 0.484 [0.102, 0.866]) demonstrated significant positive associations with Intelligence Quotient. However, none of the anthropometric indices maintained statistically significant associations with Intelligence Quotient after adjusting for potential confounders ( P -values > 0.05). Conclusions This study indicated no strong relationship between various body measurements and intelligence levels in school-aged children after adjusting the analyses for confounders. This suggests that intelligence in these children may be largely shaped by genetic and sociodemographic factors, with minimal influence from physical growth patterns....

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Time-course effects of exercise intervention on executive function in adolescents with obesity

Hu,

Shen,

Yin

et al. 2024

Front. Psychol.

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ObjectiveThis study was to investigate the developmental characteristics of executive function (EF) in obese adolescents and the time-course effects of a 14-week exercise intervention combining aerobic exercise and resistance training on EF in this population.MethodsThe experimental group of 28 obese junior high school students participated in the exercise intervention combining aerobic exercise and resistance training, while the control group of 24 healthy weight junior high school students engaged in the regular recess exercise. EF, including inhibition, working memory, and cognitive flexibility, was assessed 1 week prior to the exercise intervention and at 12 and 14 weeks post-intervention. Changes in EF sub-functions in both groups at different time points during the exercise intervention were analyzed.ResultsThe findings revealed that obese junior high school students exhibited lower levels of inhibition (p = 0.003, Cohen’s d = 0.848) and cognitive flexibility (p = 0.013, Cohen’s d = 0.706) compared to their healthy weight peers. The exercise intervention combining aerobic exercise and resistance training led to significant improvements in EF among obese junior high school students, with inhibition (p < 0.01, Cohen’s d = 0.713; p = 0.003, Cohen’s d = 0.683) and cognitive flexibility (p = 0.001, Cohen’s d = 0.797; p < 0.01, Cohen’s d = 0.890) showing significant improvement at 12 and 14 weeks post-intervention, and working memory demonstrating significant improvement at 14 weeks (p = 0.004, Cohen’s d = 0.710). No significant differences were observed in EF over time in healthy weight junior high school students.ConclusionObese adolescents had impaired EF, as evidenced by low levels of the inhibition and cognitive flexibility compared to healthy weight adolescents. The exercise intervention combining aerobic exercise and resistance training had a positive effect on EF of obese adolescents. The time-course effects of the intervention on improvements in inhibition, working memory, and cognitive flexibility varied with intervention duration in obese adolescents, with significant changes in inhibition and cognitive flexibility observed at 12 weeks and significant changes in working memory at 14 weeks.

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Efectos del sobrepeso y la obesidad en las funciones cognitivas de niños y adolescentes

Cited by 3 publications

References 60 publications

Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study

Childhood obesity and risk of Alzheimer’s disease: a Mendelian randomization study

Association of anthropometric parameters with intelligence quotient in early school-aged children: a cross-sectional study in Iran

Time-course effects of exercise intervention on executive function in adolescents with obesity

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