Efectos indirectos de la infección por citomegalovirus

Osorio, Juan José Castón; Goñi, F. Zurbano

doi:10.1016/s0213-005x(11)70050-7

Cited by 4 publications

(1 citation statement)

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“…CMV is recognized as the major infectious complication in transplant recipients producing a variety of end-organ diseases or CMV syndrome with fever and leucopenia (Cordero et al, 2012; de la Torre-Cisneros et al, 2011). In addition to directly attributable morbidity, CMV has indirect effects (Caston Osorio and Zurbano Goni 2011), including an immunomodulating activity that is likely responsible for an increased risk of additional opportunistic infections.…”

Section: Discussionmentioning

confidence: 99%

Prospective, comprehensive, and effective viral monitoring in Cuban children undergoing solid organ transplantation

et al. 2014

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PurposeIn Cuba, viral monitoring in the post-transplant period was not routinely performed. The aim of this research is to identify the most frequent viruses that affect transplanted Cuban children, by implementing a viral follow-up during the post-transplant period.MethodsThe study population included all Cuban pediatric patients who underwent solid organ transplantation (SOT) between November 2009 and December 2012. A total of 34 transplanted pediatric patients of kidney (n = 11) and liver (n = 23) were prospectively monitored during a 34-week period for viral DNAemia and DNAuria by simultaneous detection of cytomegalovirus (CMV), Epstein-Barr virus, herpes simplex virus type 1 and 2, varicella zoster virus, human herpesvirus 6, human adenovirus, and polyomaviruses (BKV and JCV) using quantitative real-time polymerase chain reaction (qRT-PCR).ResultsViral genome of at least one virus was detected in 21 of 34 recipients, 18 patients excreted virus in urine while 12 presented DNAemia. CMV (41.2%) and BKV (35.3%) were the most frequent viruses detected during the follow-up. CMV was the virus mainly associated with clinical symptoms and DNAemia. Its excretion in urine (with cut off value of 219 copies/mL) was associated with detection in plasma (p < 0.001); furthermore, CMV viruria was predictive of CMV viremia (OR:8.4, CI:2.4-29.1, p = 0.001). There was no association between high viral load and clinical complications, due to the prompt initiation of preemptive ganciclovir. Conclusion: This comprehensive viral monitoring program effectively prevents the development of critical viral disease, thus urge the implementation of qRT-PCR as routine for viral monitoring of transplanted Cuban organ recipients.

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Section: Discussionmentioning

confidence: 99%