Efeito da estimulação elétrica de alta voltagem e insulina tópica em lesão cutânea experimental

Ferreira, Rafaela; Guirro, Elaine Caldeira de Oliveira; Silva, Carlos Alberto da; Polacow, Maria L. O.

doi:10.1590/1809-2950/15311923042016

Cited by 2 publications

(1 citation statement)

References 20 publications

(21 reference statements)

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“…While wound healing conventionally follows a temporal sequence in uncomplicated cases, it is noteworthy that different regions of the wound may manifest varying stages of repair, often overlapping temporally [26]. Recent advancements in wound care have precipitated the emergence of novel therapeutic modalities targeting both acute and chronic wound healing, with the overarching objective of achieving complete lesion closure and restoration of optimal tissue function [27,28]. Notably, among these innovative approaches lies the topical application of insulin, which has exhibited considerable efficacy in promoting tissue healing [29].…”

Section: Discussionmentioning

confidence: 99%

The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats

Carreira,

Silva,

Alves

et al. 2024

Animals

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Wound healing is a complex biological process involving a coordinated sequence of events aimed at restoring tissue integrity and function. Recent advancements in wound care have introduced novel therapies, with topical insulin application emerging as a promising strategy for promoting tissue healing. This study, involving 60 female cats (n = 60) undergoing elective spaying, aimed to evaluate the effects of topical fast-acting insulin on the healing process of surgical wounds. Each surgical suture was divided into two regions: the control zone (Zcr) without insulin application and the study zone (Zst), where insulin was applied topically for 10 min every 24 h over eight consecutive days. Assessment of suture healing was conducted using an adapted scale at two time points post-surgery: T1 (day 2) and T2 (day 8). Statistically significant differences were registered in the final healing scale scores between Zcr and Zst (p < 0.022), as well as for the parameter of regional fluid (p-value = 0.017). Additionally, at T2, all Zst regions exhibited wound closure, whereas Zcr did not, although not in a statistically significant manner. The observed discrepancy at T2 between the Zcr and Zst regions may suggest a potential benefit of utilizing insulin. No side effects resulting from the insulin topical application performed by the tutors were recorded in the Zst suture group. This study represents the first exploration of the benefits of topical insulin application for surgical wound healing in cats.

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Section: Discussionmentioning

confidence: 99%

The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats

Carreira,

Silva,

Alves

et al. 2024

Animals

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Efficacy of the Novel Formulation of Topical Liothyronine and Liothyronine-insulin in Mild to Moderate Diabetic Foot Ulcer: A Randomized, Triple-blind Clinical Trial

Saghafi,

Khalilzadeh,

Ramezani

et al. 2024

CMC

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Background: Diabetic foot ulcer (DFU) is one of the challenging complications of chronic diabetes. Objective: The study aimed to investigate whether liothyronine (T3) and liothyronine-insulin (T3/Ins) topical preparations could significantly reduce the healing time of DFU. Methods: A prospective, randomized, placebo-controlled, patient-blinded clinical trial was conducted on patients with mild to moderate DFU, over a lesion area of no greater than 100 cm2. The patients were randomized to receive T3, T3/Ins, or honey cream 10% as the routine of care twice a day. Patients were examined for tissue healing weekly for 4 weeks, or until the total lesion clearance was observed, whichever was earlier. Results: Of 147 patients with DFUs, 78 patients (26 per group) completed the study and were included in the final evaluation. At the time of study termination, all participants in each of the T3 or T3/Ins groups were free of symptoms based on the REEDA score, while about 40% of participants in the control group were detected with each of grades 1, 2, or 3. A significant difference was observed on days 7, 14, and 21 of consumption of topical preparations (P-value < 0.001). The mean time to complete wound closure in the routine care group was about 60.6 days, while it was 15.9 and 16.4 days in T3 and T3/Ins groups, respectively. Within the T3 and T3/Ins groups, significant earlier wound closure was detected at day 28 (P-value < 0.001). Conclusion: T3 or T3/Ins topical preparations are effective for wound healing and acceleration of wound closure in mild to moderate DFUs.

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Efeito da estimulação elétrica de alta voltagem e insulina tópica em lesão cutânea experimental

Cited by 2 publications

References 20 publications

The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats

The Use of Fast-Acting Insulin Topical Solution on Skin to Promote Surgical Wound Healing in Cats

Efficacy of the Novel Formulation of Topical Liothyronine and Liothyronine-insulin in Mild to Moderate Diabetic Foot Ulcer: A Randomized, Triple-blind Clinical Trial

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