Efeito da sobreposição de um modelo de obesidade neuroendócrina experimental e hipertensão arterial sobre a pressão arterial, peso corporal e parâmetros metabólicos e renais de ratos

Ferreira, Lara Beatriz Delfino; Cesaretti, Mário Luís Ribeiro; Voltera, Aline Francisco; Ginoza, Milton; Kohlmann, Osvaldo

doi:10.1590/s0101-28002011000300010

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Despite this fact, the involvement of the sex-based differences in the immune reactivity in the aetiology of obesity, gender inequality remains largely understudied and poorly understood. This concerns, in particular, the neuro-endocrine form of obesity, which is caused by MSG 32 .…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Rudyk

Позур

Voieikova

et al. 2018

Sci Rep

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The important component of obesity pathogenesis is inflammatory activation of innate immune cells within adipose tissue and in other body locations. Both the course of obesity and innate immune reactivity are characterized by sex-associated differences. The aim of the work was a comparative investigation of metabolic profiles of phagocytes from different locations in male and female rats with MSG-induced obesity. The administration of monosodium glutamate (MSG) caused obesity, with sex-associated differences, that was more severe in male rats. Obesity was associated with pro-inflammatory activation of CD14+ phagocytes from adipose tissue in female, but not in male rats, which was demonstrated by decreased phagocytosis activity along with increased ROS generation. Phagocytes from the peritoneal cavity and peripheral blood of obese female rats exhibited neutral metabolic profile, whereas those cells from obese male rats displayed a pro-inflammatory metabolic profile. Thus, the manifestation of obesity-induced inflammation was characterized by different patterns of metabolic profile of phagocytes in male and female rats. Identified immune cell characteristics expand our knowledge of obesity immunobiology and may help to develop more effective preventive and therapeutic interventions for obese patients of different sexes.

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Section: Discussionmentioning

confidence: 99%

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Rudyk

Позур

Voieikova

et al. 2018

Sci Rep

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“…The neurotoxic effect of MSG in SHR can determine a lower secretion of growth hormone, and hence lower the weight gain. 17,37,38 Thus, our experimental model constitutes a model of visceral obesity, a specific type of obesity closely associated with insulin resistance. The three animal study groups did not differ in BMI but the consumption of kefir resulted in decreased abdominal, thoracic and delta abdominal circumference in the MetS animals, indicating that kefir is able to influence body fat distribution in rodents.…”

Section: Discussionmentioning

confidence: 99%

“…These animals had high blood pressure, were more resistant to peripheral insulin, and presented increased central adiposity, as demonstrated in previous studies. 37,55,56 In MetS, numerous inflammatory markers are highly associated with the degree of obesity and insulin resistance, 57,58 especially those originating from adipose tissue, suggesting that obesity is a chronic low-grade inflammatory state initiated by morphological changes in adipose tissue. 14 Adipose tissue secretes several hormones and adipocytokines leading to the development and/or aggravation of insulin resistance 59 and the development of MetS.…”

Section: Discussionmentioning

confidence: 99%

Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

et al. 2016

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There is growing evidence that kefir can be a promising tool in decreasing the risk of many diseases, including metabolic syndrome (MetS). The aim of the present study was to evaluate the effect of kefir supplementation in the diet of Spontaneously Hypertensive Rats (SHR) in which MetS was induced with monosodium glutamate (MSG), and to determine its effect on metabolic parameters, inflammatory and oxidation marker expression and glycemic index control. Thirty animals were used in this experiment. For the induction of MetS, twenty two-day-old male SHR received five consecutive intradermal injections of MSG. For the Negative Control, ten newborn male SHR received intradermal injections of saline solution (0.9% saline solution). After weaning, animals received standard diet and water ad libitum until reaching 3 months old, for the development of MetS. They were then divided into three groups (n = 10): negative control (NC, 1 mL saline solution per day), positive control (PC, 1 mL saline solution per day) and the Kefir group (1 mL kefir per day). Feeding was carried out by gavage for 10 weeks and the animals received standard food and water ad libitum. Obesity, insulin resistance, pro- and anti-inflammatory markers, and the histology of pancreatic and adipose tissues were among the main variables evaluated. Compared to the PC group, kefir supplementation reduced plasma triglycerides, liver lipids, liver triglycerides, insulin resistance, fasting glucose, fasting insulin, thoracic circumference, abdominal circumference, products of lipid oxidation, pro-inflammatory cytokine expression (IL-1β) and increased anti-inflammatory cytokine expression (IL-10). The present findings indicate that kefir has the potential to benefit the management of MetS.

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Differential benefits of physical training associated or not with l-arginine supplementation in rats with metabolic syndrome: Evaluation of cardiovascular, autonomic and metabolic parameters

Reginato

Jager

Martins

et al. 2023

Physiology & Behavior

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Efeito da sobreposição de um modelo de obesidade neuroendócrina experimental e hipertensão arterial sobre a pressão arterial, peso corporal e parâmetros metabólicos e renais de ratos

Cited by 5 publications

References 27 publications

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

Differential benefits of physical training associated or not with l-arginine supplementation in rats with metabolic syndrome: Evaluation of cardiovascular, autonomic and metabolic parameters

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