Efeitos a curto prazo de "stents" não recobertos e recobertos com politetrafluoroetileno em aorta de suínos: um modelo experimental

Grudtner, Marco Aurelio; Pereira, Adamastor Humberto; Costa, Luiz Francisco Machado da; Souza, Gilberto Goncalves de; Argenta, Rodrigo; Longhi, Joel Alex

doi:10.1590/s0102-86502004000200008

Cited by 7 publications

(11 citation statements)

References 19 publications

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“…Within the groups, differences were found among group 1 (average 3.51 ± 1.57 mm²) and 2 (average 3.70 ± 1.10 mm²) when compared to group 3 (average 5.59 ± 2.03 mm²) (LSD, p<0.05). values (lipids profile) did not show any statistically significant variation, apart from the HDL and it was inferred that these factors probably do not influence the development of the arterial lesion, These findings corroborates previous works in pigs 7 . It is well established in humans that the degree of wall lesion caused by the stent or angioplasty is related to a variable degree of intimal tickening.…”

Section: Discussionsupporting

confidence: 90%

“…Verheye et al 20 , after implanting stents in the iliac and carotid arteries of pigs, conducted histological studies of one to six months, stating that within one month the vascular wall was completely covered by endothelial-type cells. In our laboratory, we have studied the intimal tickening in a series of conditions and the time interval of four weeks was used to study the arterial wall alterations 7 . Post et al 21 performed PTA or stent implants in atherosclerotic iliac arteries in micropigs, concluding that the luminal loss after PTA, when compared to the stent implant, was due principally to geometric remodelling in the first group and to intimal hyperplasia in the second.…”

Section: Discussionmentioning

confidence: 99%

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Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Jùnior¹,

Pereira

Pasa³

2006

Acta Cir. Bras.

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PURPOSE: To compare through digital morphometry, the intimal thickening of the common ilíac arteries (CIA) in pigs, submitted to angioplasty and angioplasty followed by stent implantation. METHODS: Angioplasty was performed in 10 pigs in both CIA, followed by a stent implantation in the left CIA. After four weeks, the aorto-iliac segment was dissected. Histologic slices where divided in three groups: left CIA in the area of the proximal (group 1) and distal (group 2) implantation site of the stent and the region of angioplasty in the right CIA (group 3). The histological slices were digitalized to be analyzed by morphometry with calculation of the luminal, intimal and media layers areas. Descriptive statistics analysis was performed through average and standard deviation of areas on each group, using ANOVA, with LSD Post-Hoc test (p<0.05). RESULTS: A significant statistic difference was observed when the median area of intimal layer of the groups 1 and 2 where compared with group 3 and in the media layer area of the groups 1 and 2 when compared with group 3. No difference was observed in luminal areas among the three groups. CONCLUSION: Angioplasty followed by stent insertion produces an intimal thickening larger than that observed after simple angioplasty. However, the area of the media layer is smaller in the "angioplasty plus stent" group and there is no significant change in the luminal area among the three groups.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Jùnior¹,

Pereira

Pasa³

2006

Acta Cir. Bras.

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“…In the transitional area between the metallic struts of the stents, the translucent lining was apparently not continuous. These findings are similar to those reported by Grüdtner et al [20]. We also clearly saw that the structural changes in the aortic wall were restricted to the region in which the stent was anchored (Figures 4 and 6).…”

Section: Fig 5 -External View Of the Abdominal Aorta With One Metallsupporting

confidence: 92%

“…Grüdtner et al [20] evaluated morphological changes in the aortas of pigs submitted to the implantation of covered and non-covered stents compared to a Control Group. The authors did not find statistically significant differences among the groups in respect to the intimal thickness of the arteries between the proximal and distal segments of the stent.…”

Section: Fig 5 -External View Of the Abdominal Aorta With One Metallmentioning

confidence: 99%

“…Grüdtner et al [20], in their aforementioned work, demonstrated in a macroscopic analysis that the aortas were patent and the stents were firmly anchored to the artery wall. Moreover, a thin covering of translucent tissue was observed at the ends and the central region of the stents and on the PTFE which covered the stents.…”

Section: Fig 5 -External View Of the Abdominal Aorta With One Metallmentioning

confidence: 99%

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Reação histopatológica da parede da aorta abdominal ao stent não recoberto

Bombonato

Palma

Marcondes

et al. 2006

Rev Bras Cir Cardiovasc

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Reação histopatológica da parede da aorta abdominal ao stent não recoberto Histopathological reaction of the abdominal aorta wall to non-covered stents Abstract Objective: To evaluate the histopathological reaction of the abdominal aorta wall in pigs' renal arteries to the presence of non-covered stainless steel stents. Methods: The abdominal aorta of ten pigs (6 months old and weighing 86.6 kg on average) was histopathologically studied 100 days after the implant of stainless steel stents in the abdominal aorta, with one segment of the stent implanted in the renal artery. Self-expanding non-covered stents were released by laparotomy. The histological slices were made at the transition from the normal aorta and the aorta containing the stent; the aorta portion containing the stent; the portion with the ostia of renal arteries; periaortic lymph nodes and renal parenchyma. The samples were stained by the hematoxylin and eosin technique. Results: Macroscopic findings showed periaortic lymphadenopathy, thickened aortic wall, patency of lumbar and renal arteries and normal renal anatomical structure. Microscopic analyses near the stents revealed thickening of vessel wall secondary to intima fibrosis, and media layer affected by interstitial fibrosis. Micrometric measurements of aorta wall with the stent, compared to the aortic portion without it, presented a 75.90% increase in the total thickness of the wall by thickening of the intima layer secondary to fibroblast proliferation, collagen deposits with lymphocytary inflammatory infiltrate and foreign body-type granulomas. Conclusion: The non-covered stainless steel stents in pigs' aortas produced a significant inflammatory reaction with fibrosis in the media and intima layers evidenced by histopathological analyses; their presence did not interfere in the patency of the abdominal aorta or the renal and lumbar arteries.

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Tratamento endovascular de trauma arterial periférico com uso de stents revestidos: estudo experimental em porcos

Belczak¹

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Efeitos a curto prazo de "stents" não recobertos e recobertos com politetrafluoroetileno em aorta de suínos: um modelo experimental

Cited by 7 publications

References 19 publications

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Reação histopatológica da parede da aorta abdominal ao stent não recoberto

Tratamento endovascular de trauma arterial periférico com uso de stents revestidos: estudo experimental em porcos

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