Efeitos do butirato nos níveis de peroxidação lipídica em células da mucosa cólica sem trânsito fecal: estudo experimental em ratos

Abstract

Efeitos do butirato nos níveis de peroxidação lipídica em células da mucosa cólica sem trânsito fecal: estudo experimental em ratos

Evaluation of the anti-inflammatory and antioxidant effects of the sucralfate in diversion colitis

“…13 Based on these findings, several studies began to test the effectiveness of substances with antioxidant activity for the treatment of DC. 19,[30][31][32] The results of these studies confirmed that natural or synthetic substances with antioxidant activity were able to reduce the production of OFR and to improve the histological changes that characterize DC. 19,[29][30][31][32] Riley et al in 1989 33 were the first to demonstrate the benefits of using enemas with SCF in the acute phase of ulcerative rectitis.…”

Evaluation of topical n-acetylcysteine in diversion colitis

“…A series of studies confirmed that the irrigation of segments without fecal stream with SCFAs-rich solutions, particularly butyrate, can revert endoscopic and histological alterations related to the disease and reduce the levels of tissue oxidative stress [9][10][11][12][13]15,17,18,33,34 . The main action of SCFAs in the segment without fecal stream would be to restore homeostasis in the reactions that promote energy production by the cells, preventing the excessive formation of OFRs and, consequently, the tissue oxidative stress 34 . When considering that the use of substances with antioxidant activity can neutralize the harmful effects of OFRs, it becomes an interesting strategy for the treatment of diseases related to oxidative stress.…”

“…Studies have shown that fecal stream restoration reverts the disease symptoms in most cases, making it the most effective therapy for the prevention of DC 13 .However, fecal traffic recovery is not always possible, which promotes the evaluation of other therapeutic strategies 20 . As the pathogenesis of DC is related to deficient supply of SCFAs, the most obvious strategy is to apply enemas with SCFAs in the segment without fecal stream 18,19,33,34 . A series of studies confirmed that the irrigation of segments without fecal stream with SCFAs-rich solutions, particularly butyrate, can revert endoscopic and histological alterations related to the disease and reduce the levels of tissue oxidative stress [9][10][11][12][13]15,17,18,33,34 .…”

“…As the pathogenesis of DC is related to deficient supply of SCFAs, the most obvious strategy is to apply enemas with SCFAs in the segment without fecal stream 18,19,33,34 . A series of studies confirmed that the irrigation of segments without fecal stream with SCFAs-rich solutions, particularly butyrate, can revert endoscopic and histological alterations related to the disease and reduce the levels of tissue oxidative stress [9][10][11][12][13]15,17,18,33,34 . The main action of SCFAs in the segment without fecal stream would be to restore homeostasis in the reactions that promote energy production by the cells, preventing the excessive formation of OFRs and, consequently, the tissue oxidative stress 34 .…”

“…Studies conducted in experimental models of chemically induced colitis confirmed the beneficial effects of antioxidants, improving the inflammatory process of colonic mucosa [27][28][29][30][31] . Several drugs have been tested with effective results in experimental conditions, including 5-ASA, glucocorticoids, L-carnitine, L-glutamine, melatonin and antioxidants found in the aqueous extract of Ilex paraguariensis and Curcuma longa [33][34][35][36][37][38][39] . Unfortunately, although they are effective in the treatment of this disease, some of these substances cause side effects when used at higher doses and for longer periods 27,36 .…”