Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

El-Radaideh, Khaled M.

doi:10.1590/s0034-70942007000100004

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…There was not any significant difference between the first and the third group (P > 0.05), but the difference between the forth (placebo) and the other three groups was significant (P > 0.05). There was also a significant difference between the groups receiving lidocaine and the one who received paracetamol (P < 0.05).In conclusion, Khaled reported that lidocaine can relive the propofol injection pain up to 70% (13). …”

Section: Discussionmentioning

confidence: 78%

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Gharavi¹,

Sabzevari²,

Ghorbanian³

et al. 2014

Iran Red Crescent Med J

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Background:Propofol is one of common anesthetic drugs used in anesthesia. The most common side effects of propofol are local pain. Pretreatment with lidocaine can reduce propofol injection pain.Objectives:The aim of the present study was to assess and compare the efficiency of lidocaine 0.4% and 2% in reducing the incidence and severity of propofol injection pain.Patients and Methods:This was a double blind prospective clinical trial on children 4-8 years old with class ASA I and II candidates who were referred to Dr. Shaikh Hospital in Mashhad for elective surgery. Sample size calculated 50 patients in each groups based on pilot study. 100 children's were randomly divided equally in two groups, who were injected with lidocaine solutions 2% and 0.4% respectively. patient's pain evaluation based on VSD (verbal descriptor scale) and NRS (Numeric Rating Scale) using patient's verbal reaction and behavior namely fretting, hand drag and tearing. The collated data was analyzed.Results:There was nosignificant difference as to the first three variables (age, gender and weight P > 0.2). The significant difference regarding pain experience in both groups was noteworthy (P > 0.2).Conclusions:Most of the studies compared lidocaine with other drugs or its efficiency at different doses. Our study is different in that we applied a constant dose of lidocaine in various volumes and concentration. This result shows that lidocaine with the same does but lower concentration and higher volume is more effective in preventing propofol injection pain. Using diluted lidocaine with the dosage of 1 mg/kg and a concentration of 0.4% is an effective way to relieve pain caused by propofol injection in children.

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Section: Discussionmentioning

confidence: 78%

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Gharavi¹,

Sabzevari²,

Ghorbanian³

et al. 2014

Iran Red Crescent Med J

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“…According to our results, Paracetamol reduces propofol injection pain up to 28.57%, which is slightly different from the results of other studies. In Radaideh’s study, 54% of the paracetamol group had no pain (5). Borazan et al investigated the effects of lidocaine with different doses of paracetamol on the reduction of propofol injection pain.…”

Section: Discussionmentioning

confidence: 99%

“…In a study which was carried out in September 1999 by Ramer and colleagues, it was determined that the pain severity after propofol injection without anesthesia, was approximately 70%, which is not associated with the size of catheter (IV) or propofol infusion rate. In addition, the results of Radaideh’s study in 2007 on 200 patients, indicated that 4 cc of lidocaine 1% reduces the pain of propofol injection by 68 % (5). The results of these studies are consistent with our findings, indicating that lidocaine reduces the pain of propofol injection up to 69.64%.…”

Section: Discussionmentioning

confidence: 99%

“…Also, The drugs which have been studied to decrease the pain included different doses of lidocaine (5-9), NSAIDs (5), metoclopramide (6), opiates such as morphine, meperidine, fentanyl (7) tramadol (2), thiopental sodium (4), nafamostatmesilate (10), ketamine (8, 11), ondansetron (12) granisetron (13, 14) magnesium sulfate (8, 15-18) and paracetamol (9, 19), have been associated with different results.…”

Section: Introductionmentioning

confidence: 99%

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Paracetamol, Ondansetron, Granisetron, Magnesium Sulfate and Lidocaine and Reduced Propofol Injection Pain

Alipour¹,

Tabari²,

Alipour³

2014

Iran Red Crescent Med J

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Background:Propofol is a most widely used intravenous anesthetic drug. One of its most common complications is the pain upon injection; therefore, different methods, with various effects, have been proposed in order to alleviate the pain.Objectives:This study investigates the effects of paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine drugs on reducing the pain of propofol injection during anesthetic induction. Also, the hemodynamic changes will be analyzed.Patients and Methods:This is an interventional study containing 336 patients underwent elective orthopedic surgeries in Educational Hospitals of Mashhad University, using systematic sampling, the patients were divided into six groups. A 20-gauge needle was inserted into a venous vessel in the back of the hand and 100 cc of Ringer serum was injected into the vein, which was applied proximal to the injection site. Afterwards, paracetamol 2 mg/kg (group p), magnesium sulfate 2 mmol (group M), ondansetron 4 mg (group O), granisetron 2 mg (group G), lidocaine 40 mg (group L) and 5 cc saline (group S) were injected into the vessel, after 60 seconds, the tourniquet was opened. One quarter of the total dose of propofol (2.5 mg/kg) was injected with a flow rate of 4 mg/sec and then the injection pain was measured. Finally, the fentanyl (2 µg/kg), atracurium 0.5 mg/kg, and the remaining dose of propofol were injected and the vital signs were recorded before the administration of propofol and 1, 3, 5 and 10 minutes after the propofol injection.Results:The six groups did not significantly differ, regarding their gender, weight or age. Propofol injection pain was less in L and G groups, in comparison with the others (P ≤ 0.001). By analyzing the hemodynamic changes, it was observed that the least amount of change in mean arterial pressure was observed in the paracetamol group.Conclusions:The reduction of propofol injection pain was observed by using medications (in comparison with normal saline), but it was more significant in groups G and L. Moreover, Hypotension was higher in groups S and G and it was lessened in group P.

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“…This is a much higher reduction than our study findings (51.35% pain free), which might be related to the additional use of diclofenac 50 mg and fentanyl 2.5 U/kg before propofol injection. El-Radaideh studied the effect of 40 mg paracetamol pretreatment on propofol injection pain and concluded that 54% of the patients were pain free [15]. Paracetamol has been used for propofol injection pain in doses ranging from as low as 40 mg to 1 g. However, we found that 1 g of IV paracetamol in combination with lidocaine pretreatment is superior to lidocaine pretreatment alone in reducing pain associated with propofol administration.…”

Section: Discussionmentioning

confidence: 83%

Efficacy of Intravenous Paracetamol in Combination with Lidocaine Pretreatment for Reducing Pain During Injection of Propofol

Hayat

Afshan

Nasir

et al. 2020

Cureus

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Efeitos do tratamento prévio com lidocaína, paracetamol e lidocaína-fentanil por via venosa na dor causada pela injeção de propofol: estudo comparativo

Cited by 9 publications

References 20 publications

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Paracetamol, Ondansetron, Granisetron, Magnesium Sulfate and Lidocaine and Reduced Propofol Injection Pain

Efficacy of Intravenous Paracetamol in Combination with Lidocaine Pretreatment for Reducing Pain During Injection of Propofol

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