Efeitos dos anabolizantes sobre a densidade de neurônios dos núcleos da base

Freitas, Ariane Cristine de; Damião, Bruno; Alves, Débora Mantoan; Ribeiro, Melissa; Fernandes, Geraldo José Medeiros; Rossi, Wagner Costa; Esteves, Alessandra

doi:10.1590/1517-869220172303151688

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…These data combined suggest that AAS use during adolescence can lead to behavioral effects more pronounced and lasting than in adults [11,12]. Different researchers also indicate that AAS use increases the chances of neuron death in different brain regions in mice [13,14,15].…”

Section: Introductionmentioning

confidence: 87%

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Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Silva¹

2018

AJSS

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This study analyzed the effects of the chronic use of these drugs on the neuronal density of mice cerebral cortex and hippocampus. Materials and methods: 40 male Swiss mice were used, divided into 4 groups (n=10): GI-Control (0,02ml/Kg/week of saline solution), GII-treated with anabolic steroid Durateston® (83,3mg/Kg/week) GIII-treated with anabolic steroid Deca Durabolin® (16,6mg/Kg/week) e GIV-treated with the two anabolic steroids, concomitantly. The mice were treated for sixty days (60) and practiced swimming three times a week. The brain fragments were processed following the standardized sequence in conventional histological procedures and stained using cresyl violet. For the neuronal density analysis, the simple random count methodology was used. Results: Data revealed a significant reduction in the neuronal density of the groups treated with anabolic steroids, the limbic area had an estimated decrease of 16.44% in group III and 29.21% in group IV; the motor area the groups II, III, and IV presented a reduction of 17.63%, 15.35%, and 12.23%, and in the sensory area 15.22%, 16.41% and 21.59%, respectively; the groups II, III, and IV of the Ca1 area of the hippocampus showed a neuronal loss of 23.5%, 27.8%, and 36.36%, while groups II, III and IV of the Ca2 area there was a reduction of 10.37%, 11.83%, and 16.34%. In conclusion, the chronic use of AAS can be harmful to the nervous system since the neuronal reduction can bring structural and functional damages with possible consequences the whole organism.

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Section: Introductionmentioning

confidence: 87%

“…Encephalon fragments were processed following standardized histological procedure [13,15]. To estimate the neuron density, simple random sampling method was used [22,23,24,25].…”

Section: Methodsmentioning

confidence: 99%

Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Silva¹

2018

AJSS

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“…These results are in agreement with previously published outcomes. 28,29 In general, it seems that AAS physiological doses have the ability to play a neuroprotective role; however, when AAS is administered in high concentrations, they appear to exert a deleterious effect on neuron body cells, and most studies show an excitotoxic effect when using concentrations. The same was observed by some other authors, who found that pre-treatment with high doses of testosterone increased Nmethyl-D-aspartate (NMDA) toxicity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Supraphysiological Doses of Testosterone Cypionate and Stanozolol on Neuronal Density of Basolateral and Medial Amygdala and on the Anxious Behavior of Mice

et al. 2019

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Supraphysiological doses of anabolic-androgenic steroids (AAS) have been associated to possible nerve tissue damage and behavioral effects. Considering the lack of knowledge of the neural aspects involved in these behavioral alterations, this work aimed to analyze the anxious behavior response or aggressiveness, besides quantifying the neuronal density of the basolateral amygdala (BLA) and of the ventral posterior nucleus (VPN) of the medial amygdala. The animals received doses of testosterone cypionate (CT Group) and stanozolol (ST Group) twice a week for 33 days. The effects of chronic administration of AAS related to anxious behavior (as determined by the elevated plus maze [EPM] test) in male animals are observed in a lower number of entries (< 45.25%), and a shorter staying time spent in the open arms (< 41.9%) was observed in the ST. In female animals, a longer staying time spent in the closed arms of the EPM test was observed in the CT (> 15%) as well as a shorter staying time spent in the open arms for CT (< 17.1%) also to ST (< 52.1%). Regarding the neuronal density in BLA, a significant reduction in neuronal density of male animals (17.55%) was observed only in CT, whereas for females, significant differences were found in CT (19.16%) and ST (18.36%). The reduction of neuronal density in VPN in male animals was 13.55% in CT and 17.68% in ST, whereas in group of females it was 13.53% and 14.32%, respectively for CT and ST. Therefore, the two steroids used in this experiment were able to significantly reduce neuronal density in two analyzed areas, regardless of sex, suggesting that indiscriminate use of these substances causes death of brain amygdala neurons.

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“…The treatment consisted in application of two anabolic steroids, the first, nandrolone decanoate marketed under the name Deca Durabolin® and the second an association of testosterone propionate, testosterone fenpropionate, testosterone isocaproate and testosterone decanoate marketed under the name of Durateston ®. The animals were treated for one (1) month, the doses of 0.02 ml physiological solution being that of Durateston® 83.3 mg / kg (0.02 ml) and the doses of Deca Durabolin® 16.6 mg / kg (0.02 ml) applied once a week [14][15][16][17][18].…”

Section: Methodsmentioning

confidence: 99%

Anabolic Steroids Effects on Bone Regeneration

Pansieri¹,

Esteves²,

Rossi³

2019

AJSS

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In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of socalled "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.

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Efeitos dos anabolizantes sobre a densidade de neurônios dos núcleos da base

Abstract: RESUMOObjetivos: Pouco se sabe sobre a atuação dos esteroides androgênicos anabolizantes (EAA) no cé-rebro humano e, por isso, resolvemos estudar a perda neuronal causada pelo uso e abuso de EAA em camundongos. Métodos

Cited by 7 publications

References 21 publications

Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Effects of Supraphysiological Doses of Testosterone Cypionate and Stanozolol on Neuronal Density of Basolateral and Medial Amygdala and on the Anxious Behavior of Mice

Anabolic Steroids Effects on Bone Regeneration

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