Efektivitas Ekstrak Daun Afrika (Vernonia amygdalina) Secara Topikal Untuk Reepitelisasi Penyembuhan Luka Insisi Pada Tikus Putih (Rattus novergicus)

Putrianirma, Rizki; Triakoso, Nusdianto; Yunita, Maya Nurwartanti; Yudaniayanti, Ira Sari; Hamid, Iwan Sahrial

doi:10.20473/jmv.vol2.iss1.2019.30-35

Cited by 9 publications

(7 citation statements)

References 2 publications

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“…The 20% egg white gel quickly dries and forms a rough crust (scab) over the wound area. However, cleaning or removing this blockage will create a new wound on the skin, causing bleeding that prolongs the inflammatory phase and inhibits new tissue generation and wound healing (Putrianirma et al, 2019). This argument corresponds to the theory proposed by (Simanjuntak, 2006) , i.e., applying a preparation with high concentrations on a small wound surface causes a buildup of the preparation on the top layer of the membrane.…”

mentioning

confidence: 74%

“…In group 4, the wound did not immediately close because it was treated with a gel composed of a higher extract concentration that dried and formed a rough crust (scab) over it. Cleaning or removing this scab will create a new wound, causing bleeding that prolongs the inflammatory phase and inhibits the tissue remodeling phase of healing (Putrianirma et al, 2019).…”

Section: Effects Of Free-range Chicken Egg White Gel On Wound-size Reductionmentioning

confidence: 99%

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Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice

et al. 2021

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mentioning

confidence: 74%

Section: Effects Of Free-range Chicken Egg White Gel On Wound-size Reductionmentioning

confidence: 99%

Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice

et al. 2021

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“…After incisions were made to all the test animals, treatment was carried out according to the signs of the test group and the control group. Treatment is given 2 times a day in the morning and evening (Putrianirma et al, 2019).…”

Section: Preparation and Treatment Of Test Animalsmentioning

confidence: 99%

EFFECTIVENESS OF MANALAGI MANGGO LEAF EXTRACT GEL (Mangifera indica L.) ON CUTTING WOUND HEALING IN MALE RABBITS NEW ZEALAND WHITE

Luthfiyanti,

Muktamaroh,

Khasanah

2023

icohetech

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Wounds are pathological conditions that occur in skin tissue and mucous membranes of other tissues. Mango leaves (Mangifera indica L.) contain alkaloids, flavonoids, tannins and saponins which have an effect on wound healing. The purpose of this study was to determine the effectiveness of mango leaf extract gel concentration (Mangifera indica L.) on wound healing in rabbits. The test animals were divided into five treatments, namely positive control, negative control, and gel preparation with 3 variations of extract concentration, namely formula I (10%), formula II (15%), and formula III (20%). This research is an experimental study with observations for 14 days. The statistical test uses the Anova test and the Post-Hoc test. The average healing time of the positive control and negative control groups with mango leaf extract gel (Mangifera indica L.) concentrations of 10%, 15%, and 20% had a significant difference with a sig 0.000 result (P<0.05). Manalagi mango leaf extract gel (Mangifera indica L.) provides the best wound healing effect at a concentration of 20%.

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“…Luka sering terjadi pada kulit, yang akan menyebabkan kerusakan pada epitel kulit atau gangguan konstruksi fisik khas jaringan karena cedera. Luka insisi atau terpotong dapat terjadi karena kesengajaan misal luka operasi atau kecelakaan misal karena benda tajam [1].…”

Section: Pendahuluanunclassified

Formulating Oil Emulgel of Nyamplung (Calophyllum inophyllum L) with Variations of HPMC and Activity Testing for Incision in Rabbit New Zealand

Cahya

Ekowati

Ningsih

2022

IJPE

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Emulgel is an emulsion of both O/W and W/O which is made into a gel by mixing it with a gelling agent. One of the gelling agents that is often used is HPMC because it can produce a clear gel, easily soluble in water, and has low toxicity. Nyamplung oil has wound healing activity by stimulating cell proliferation and the production of collagen and GAG (glycosaminoglycans). The purpose of this study was to find out that nyamplung (Calophyllum inophyllum L) oil can be made into a good emulgel preparation, has the effect of healing cuts, to determine the effect of variations in HPMC concentration on the physical quality and stability of the emulgel, and in accelerating the healing of cuts. This study used three formulas containing 1%, 2%, and 3% HPMC plus one control formula. Emulgel is made by mixing emulsion with gel and contains 1% nyamplung oil, then physical quality tests are carried out : organoleptic, homogeneity, pH, adhesion, dispersibility, viscosity test, emulgel type test, stability test. The wound healing activity test was carried out on the back of New Zealand rabbits. The percentage of treatment results were statistically analyzed. The results showed that all nyamplung oil emulgel formulas could be made ini emulgel preparations, had good physical quality and stability and had the effect of wound healing. The effect of gelling agent concentration affects the speed of wound healing. The result of the most optimal wound healing activity test is the formula 2.

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Efektivitas Ekstrak Daun Afrika (Vernonia amygdalina) Secara Topikal Untuk Reepitelisasi Penyembuhan Luka Insisi Pada Tikus Putih (Rattus novergicus)

Cited by 9 publications

References 2 publications

Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice

Incision wound healing activity of free-range chicken (Gallus domesticus) egg white gel in mice

EFFECTIVENESS OF MANALAGI MANGGO LEAF EXTRACT GEL (Mangifera indica L.) ON CUTTING WOUND HEALING IN MALE RABBITS NEW ZEALAND WHITE

Formulating Oil Emulgel of Nyamplung (Calophyllum inophyllum L) with Variations of HPMC and Activity Testing for Incision in Rabbit New Zealand

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