Effect analysis of peg-interferon on chronic hepatitis B virus infection

Abstract

Objective To observe the effect of Polyethylene glycol interferon α (PEG-IFN α) on chronic hepatitis B(CHB) virus infection . Methods 152 patients treated with PEG-IFN α were retrospectively analyzed. The main evaluation indexes were the degree of HBsAg decline and its influencing factors. Results among 152 patients followed up, 39 patients (25.7%) had HBsAg decreased by more than 1log10IU/ml. The clinical cure rate of HBsAg (-) patients with HBsAg < 1500IU/ml was 15.9%. Treatment duration, Alanine Transaminase elevation at 12/24 weeks, baseline HBeAg status and baseline HBsAg level were the factors influencing HBsAg decline. Conclusion The lower the baseline HBsAg level and the longer the treatment course, the more favorable it is to the decline of HBsAg.Elevated Alanine Transaminase(ALT) at 12/24 weeks was a predictor of HBsAg decline. Patient compliance is important.